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Impaired humoral immunity is associated with prolonged COVID-19 despite robust CD8 T cell responses
Institution:1. Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA;2. Division of Hematology/Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA;3. Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA;4. Lymphoma Service, Division of Hematologic Malignancies, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA;5. Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA;6. Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA;7. University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, USA;8. Infectious Diseases Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA;9. Clinical Microbiology Service, Department of Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA;10. Clinical Chemistry Service, Department of Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA;11. Memorial Sloan Kettering Cancer Center, New York, NY, USA;12. Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA;13. Physiology, Biophysics & Systems Biology, Weill Cornell Medicine, Weill Cornell Medical College, New York, NY, USA;14. Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA 19104, USA;15. Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA
Abstract:
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  • Keywords:cancer  COVID-19  SARS-CoV-2  convalescent  T cell  CD20  rituximab
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