Tissue Dielectric Constant Differentials between Malignant and Benign Breast Tumors |
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| Institution: | 1. Dr. Kiran C. Patel College of Allopathic Medicine, Nova Southeastern University, Davie, FL;2. Division of Surgical Oncology, Department of Surgery, Miller School of Medicine, University of Miami, FL;1. Department of Radiology, Obafemi Awolowo University/Obafemi Awolowo University Teaching Hospitals Complex, Ile Ife, Nigeria;3. Department of Surgery, Obafemi Awolowo University/Obafemi Awolowo University Teaching Hospitals Complex, Ile Ife, Nigeria;5. Department of Community Health, Obafemi Awolowo University/Obafemi Awolowo University Teaching Hospitals Complex, Ile Ife, Nigeria;6. Department of Radiology, Lagos State University/Lagos State University Teaching Hospital, Lagos, Nigeria;1. Department of Lymphoma, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, The Sino-US Center for Lymphoma and Leukemia Research, Tianjin, China;2. Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin, China;3. Key Laboratory of Cancer Prevention and Therapy, Tianjin, China;4. Tianjin''s Clinical Research Center for Cancer, Tianjin, China;5. Third Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Tianjin, China;6. Department of Breast Cancer Pathology and Research Laboratory, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Tianjin, China;1. Department of Plastic and Reconstructive Surgery, IFO – “Regina Elena” National Cancer Institute, Rome, Italy;2. Medicinaplasticaroma Center, Plastic Surgery, Rome, Italy;1. Health data and assessment department, Survey Data Science and Assessment Division, National cancer institute, Boulogne-Billancourt, France;2. Loire-Atlantique/Vendée Cancer Registry, Nantes, France;3. CERPOP, Université de Toulouse, Toulouse, France;4. Santé Publique France, French National Public Health Agency, Saint-Maurice, France;5. Public health division, National cancer institute, Boulogne-Billancourt, France;6. National cancer Institute, Boulogne-Billancourt, France;7. Survey Data Science and Assessment Division, National cancer institute, Boulogne-Billancourt, France;8. Aix Marseille Univ, INSERM, IRD, Economics and Social Sciences Applied to Health & Analysis of Medical Information (SESSTIM), Marseille, France |
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| Abstract: | IntroductionThis study's purpose was to characterize tissue dielectric constant (TDC) values of malignant and benign breast tumors and assess the potential utility of TDC differentials to help distinguish between malignant and benign tumors.MethodsPrior to their diagnostic biopsy, TDC was measured at 300 MHz in 59 women with previously detected breast tumors. TDC measurements were made by touching skin directly over the tumor and on the non-affected breast with a hand-held 22 mm diameter probe. Each measurement took less than 10 seconds. An inter-breast TDC ratio (RATIO) was calculated as the ratio of the tumor breast TDC value divided by the non-affected breast TDC value measured on the contralateral breast at a corresponding anatomical site. Absolute TDC values and RATIOS were compared for malignant and benign tumors based on post-measurement biopsy determinations.ResultsBiopsy findings indicated tumors were malignant in 29 patients and benign in 30. Compared to the non-affected breast, malignant tumor TDC values were greater (P = .0002) whereas for benign tumors, there was no inter-breast difference (P = .256). No patient with a benign tumor exceeded a RATIO of 1.15 whereas 12 of the 29 patients with malignant tumors exceeded this threshold and tended to have larger volume tumors.ConclusionA tentative threshold RATIO of 1.15 may be discriminatory between malignant and benign tumors if the tumor is sufficiently large. Further research using a probe with a greater penetration depth is warranted to potentially increase discrimination. |
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