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A druggable addiction to de novo pyrimidine biosynthesis in diffuse midline glioma
Affiliation:1. Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA;2. Department of Neurosurgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02215, USA;3. Department of Radiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02215, USA;4. Children’s Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA;5. Lurie Family Imaging Center, Center for Biomedical Imaging in Oncology, Dana-Farber Cancer Institute, Boston, MA 02210, USA;6. Center for DNA Damage and Repair, Dana-Farber Cancer Institute, Boston, MA 02215, USA;7. Division of Molecular and Cellular Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA;8. Center for Childhood Cancer and Blood Diseases, Nationwide Children’s Hospital, Columbus, OH 43205, USA;9. Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH 43210, USA;10. Department of Radiation Oncology, Brigham and Women’s Hospital, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02215, USA;11. Department of Pathology, Harvard Medical School Boston, Boston Children’s Hospital, 300 Longwood Avenue, Bader 104, Boston, MA 02115, USA;12. Department of Pediatric Oncology, Dana-Farber Boston Children’s Cancer and Blood Disorders Center, Boston, MA 02115, USA;13. Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA;14. Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA;15. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA;16. Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA
Abstract:
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  • Keywords:diffuse midline glioma  diffuse intrinsic pontine glioma  DHODH  ATR  replication stress  BAY2402234  pyrimidine degradation  DPYD  elimusertib
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