慢性阻塞性肺疾病炎症反应研究进展

目前研究显示气道炎症是慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)发病过程中的一个关键环节,中性粒细胞、淋巴细胞和肺泡巨噬细胞等多种炎症细胞和白三烯B4、白介素8、肿瘤坏死因子α、白介素6、基底细胞间黏附分子等多种炎症介质参与并影响气道炎症的发生.认识COPD炎症反应的特点和影响因素,能对COPD发生机制的探讨和临床治疗产生深远的影响.

Research advancement on inflammatory response of chronic obstructive pulmonary disease

At present,studies have shown that airway inflammation is a key element in the invasion process of chronic obstructive pulmonary disease(COPD),various inflammatory cells such as neutrophils,lymphocytes and alveolar macrophages and kinds of inflammatory mediators such as leukotriene B4,interleukin-8,tumor necrosis factor-α,interleukin-6,intercellular adhesion molecular-1 participate and influence the occurrence of airway inflammation.Understanding the characteristics and impact factors of inflammatory response in COPD can bring about a far-reaching impact for the mechanism of the occurrence and the clinical treatment of COPD.