Absorption performance of iodixanol-imprinted polymers in aqueous and blood plasma media |
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| Authors: | Zhan Liu David G Bucknall Mark G Allen |
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| Institution: | 1. School of Polymer, Textile and Fiber Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA;2. School of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA;1. Department of Mechanical Engineering, Chung Yuan Christian University, Chung Li 32023, Taiwan;2. Center for Biomedical Technology (CBT), Chung Yuan Christian University, Chung Li 32023, Taiwan;1. Department of Materials Science, Fudan University, Handan Road No. 220, Shanghai 200433, PR China;2. Department of Interface, Physicochemistry and Polymers, Institut Europeen des Membranes, UMR ENSCM-UM2-CNRS 5635, Universite Montpellier 2, Place Eugene Bataillon, 34095 Montpellier, France;3. Sixth People’s Hospital, Shanghai Jiaotong University, Shanghai 200233, PR China;1. U.S. Pharmacopeia Brasil Ltda, 06460-120, Barueri, SP, Brazil;2. Departamento de Química, Universidade Federal de São Carlos, 13565-905, São Carlos, SP, Brazil;1. Damghan University, School of Chemistry, Damghan, P.O. Box 36715-364, Iran;2. Young Researchers and Elite Club, Yadegar-e-Imam Khomeini (RAH) Branch, Islamic Azad University, Tehran, Iran;1. Institute of Bioanalytical Chemistry, Center for Biotechnology and Biomedicine, University of Leipzig, 04103 Leipzig, Germany;2. Institute for Physics, Martin-Luther-University Halle-Wittenberg, 06120 Halle/Saale, Germany;3. Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK |
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| Abstract: | This paper presents the preparation and absorption performance of iodixanol-imprinted polymers in aqueous and blood plasma media in vitro for biomedical applications. The imprinted polymers were prepared by non-covalent imprinting of iodixanol in a matrix of poly(4-vinylpyridine) crosslinked by ethylene glycol dimethacrylate. The binding capacities (BCs) were investigated as a function of template-to-monomer, as well as monomer-to-crosslinker, ratios in the polymerization, and the solvent type. The highest BC of iodixanols achieved from the optimized imprinted polymer in the aqueous solution is 284 mg g?1 dry polymer with an imprinting effect (IE) 8.8 times higher than that of the non-imprinted polymer. In blood plasma, the BC of this polymer is slightly reduced to 232 mg g?1 with a smaller IE 4.3 times higher than that of the control polymer. The BCs of molecularly imprinted polymers as a function of the initial assay solution concentration as well as the examination time are also addressed. Surface analyses were additionally performed to characterize the surface morphologies and porosities of synthetic polymers. This work has demonstrated the feasibility of molecular imprinting of iodixanol, and the observed absorption performance of the imprinted polymers is encouraging for biomedical applications. |
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