直肠癌患者伊立替康化疗敏感性与拓扑异构酶1水平的关系

目的:探讨直肠癌患者伊立替康化疗敏感性与拓扑异构酶1(TOPO-1)水平的关系.方法:纳入江南大学附属医院2017年1月-2019年6月接受伊立替康化疗的直肠癌患者80例.收集其临床资料,包括性别、年龄、临床分期、分化程度、病理类型.化疗8个周期后观察患者的近期疗效,将治疗无效者视为伊立替康化疗不敏感,将治疗有效者视为...

Chemotherapy sensitivity of irinotecan and its relationship with topoisomerase 1 level in the patients with rectal cancer

Objective:To explore chemotherapy sensitivity of irinotecan and its relationship with topoisomerase 1 level in the patients with rectal cancer.Methods:Eighty patients with rectal cancer who received irinotecan chemotherapy in the Hospital Affiliated to Jiangnan University from January 2017 to June 2019 were included in the study.Clinical data,including gender,age,clinical stage,differentiation degree and pathological type were collected for study.After 8 cycles of chemotherapy,observations were made in the short-term effects of the patients.Those who failed to respond to the treatment were regarded as insensitive,and those who responded to the treatment were regarded as sensitive,and they were respectively designated as the insensitive and sensitive groups.On the 2nd day after admission,the pathological tissues of the patients were collected and the expression levels of TOPO-1 were detected and compared between the patients of the two groups.The receiver operating characteristic(ROC)curve of the patients was plotted to analyze the evaluation value of TOPO-1 in chemotherapy sensitivity of irinotecan.Serum carbohydrate antigen 19-9(CA19-9)and carcinoembryonic antigen(CEA)levels were measured at admission and after 8 cycles of chemotherapy,and the serum indexes were compared between the two groups.The correlation between TOPO-1 level and serum levels of CA19-9 and CEA was analyzed by Pearson linear correlation.Results:Of the 80 patients,32(40.00%)were partially remittent,26 patients(32.50%)were stable and 22 patients(27.50%)were without remission.The expression level of TOPO-1 in the sensitive group was significantly higher than that in the insensitive group[(16.39±3.26)%vs(11.28±2.11)%,(P<0.05)].The area under the curve of TOPO-1 expression for the evaluation of chemotherapy sensitivity to irinotecan was 0.780(standard error=0.054,P<0.001,95%CI:0.675-0.886).The serum levels of CA19-9 and CEA in the sensitive group were significantly lower than those before treatment,and also lower than those in the insensitive group after treatment(P<0.05).Pearson linear correlation test showed that TOPO-1 was positively correlated with the serum levels of CA19-9 and CEA(r=0.817,P<0.001;r=0.701,P<0.05).Conclusion:The expression level of TOPO-1 in the tumor tissues of the patients in the sensitive group was significantly higher than that of the patients in the insensitive group,and there was a positive correlation between the expression level of TOPO-1 and the serum levels of CA19-9 and CEA.