Influence of lactose addition to gentamicin-loaded acrylic bone cement on the kinetics of release of the antibiotic and the cement properties |
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| Authors: | Gloria Frutos José Ygnacio Pastor Noelia Martínez María Rosa Virto Susana Torrado |
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| Institution: | 1. Departamento de Estadistica e Investigación Operativa, Universidad Complutense de Madrid, Facultad de Farmacia, E28040 Madrid, Spain;2. Departamento de Ciencia de Materiales, Universidad Politécnica de Madrid, ETSI Caminos, Canales y Puertos, E28040 Madrid, Spain;3. Departamento de Farmacia y Tecnología Farmacéutica, Universidad Complutense de Madrid, Facultad de Farmacia, E28040 Madrid, Spain;1. Craniofacial Research Center, Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital at Linkou, Chang Gung University, College of Medicine, Taoyuan, Taiwan;2. Department of Chemical and Materials Engineering, Chang Gung University, Taoyuan, Taiwan;3. Biomedical Engineering Research Laboratories, Industrial Technology Research Institute, Hsinchu, Taiwan;4. Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital at Keelung, Chang Gung University, College of Medicine, Keelung, Taiwan;1. Department of Orthopaedics, University of Zurich, Balgrist University Hospital, Zürich, Switzerland;2. Department of Radiology, University of Zurich, Balgrist University Hospital, Zürich, Switzerland |
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| Abstract: | The purpose of this study was to characterize a poly(methyl methacrylate) bone cement that was loaded with the antibiotic gentamicin sulphate (GS) and lactose, which served to modulate the release of GS from cement specimens. The release of GS when the cement specimens were immersed in phosphate-buffered saline at 37 °C was determined spectrophotometrically. The microstructure, porosity, density, tensile properties and flexural properties of the cements were determined before and after release of GS. A kinetics model of the release of GS from the cement that involved a coupled mechanism based on dissolution/diffusion processes and an initial burst effect was proposed. Dissolution assay results showed that drug elution was controlled by a diffusion mechanism which can be modulated by lactose addition. Density values and mechanical properties (tensile strength, flexural strength, elastic modulus and fracture toughness) were reduced by the increased porosity resulting from lactose addition, but maintained acceptable values for the structural functions of bone cement. The present results suggest that lactose-modified, gentamicin-loaded acrylic bone cements are potential candidates for use in various orthopaedic and dental applications. |
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