| 没药中一个新的杜松烷型倍半萜 |
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| 引用本文： | 王超超,夏晖,梁乃允,王嵘晔,王鑫玉,姚会娜,霍会霞,屠鹏飞,李军.没药中一个新的杜松烷型倍半萜[J].药学学报,2021(3):831-834. |
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| 作者姓名： | 王超超 夏晖 梁乃允 王嵘晔 王鑫玉 姚会娜 霍会霞 屠鹏飞 李军 |
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| 作者单位： | 北京中医药大学中药学院中药现代研究中心 |
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| 基金项目： | 国家重点研发计划“中医药现代化研究”重点专项资助项目(2019YFC1711000,2018YFC1707300)。 |
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| 摘 要： | 采用硅胶、ODS及半制备型HPLC等色谱分离技术,对没药正己烷提取物化学成分进行系统的分离纯化,结合其理化性质、波谱数据(UV、IR、MS、NMR)和X-ray单晶衍射实验鉴定化合物的结构。从没药正己烷提取物中分离鉴定了5个杜松烷型倍半萜类化合物,分别鉴定为(3S,4R)-3,9-二甲氧基没药酮(1)、9-甲氧基没药酮(2)、没药酮(3)、commiterpene B(4)和comosoneⅡ(5)。其中化合物1为新化合物,通过X-ray单晶衍射实验确定了其绝对构型。化合物5为首次从该属植物中分离得到。
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| 关 键 词： | 没药 橄榄科 没药属 杜松烷型倍半萜 |
A new cadinane-type sesquiterpenoid from Commiphora myrrha |
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| WANG Chao-chao,XIA Hui,LIANG Nai-yun,WANG Rong-ye,WANG Xin-yu,YAO Hui-na,HUO Hui-xia,TU Peng-fei,LI Jun.A new cadinane-type sesquiterpenoid from Commiphora myrrha[J].Acta Pharmaceutica Sinica,2021(3):831-834. |
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| Authors: | WANG Chao-chao XIA Hui LIANG Nai-yun WANG Rong-ye WANG Xin-yu YAO Hui-na HUO Hui-xia TU Peng-fei LI Jun |
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| Institution: | (Modern Research Center for Traditional Chinese Medicine,School of Chinese Materia Medica,Beijing University of Chinese Medicine,Beijing 100029,China) |
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| Abstract: | Five cadinane-type sesquiterpenoids were isolated from the n-hexane extract of Commiphora myrrha by using various chromatographic techniques,including silica gel,ODS and semi-preparative HPLC.Their structures were identified by physicochemical properties and spectroscopic data.These compounds were defined as(3 S,4 R)-3,9-dimethoxymyrrhone(1),9-methoxymyrrhone(2),myrrhone(3),commiterpene B(4)and comosoneⅡ(5).Compound 1 is a new compound,of which the absolute configuration was established by single crystal X-ray crystallographic analysis.Compound 5 is firstly isolated from the Commiphora genus. |
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| Keywords: | Myrrha Burseraceae Commiphora cadinane-type sesquiterpenoids |
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