Local application of fluvastatin improves peri-implant bone quantity and mechanical properties: A rodent study |
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| Authors: | Yasuko Moriyama Yasunori Ayukawa Yoichiro Ogino Ikiru Atsuta Mitsugu Todo Yoshihiro Takao Kiyoshi Koyano |
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| Affiliation: | 1. Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University, Fukuoka 812-8582, Japan;2. Research Institute for Applied Mechanics, Kyushu University, Fukuoka, Japan;1. Department of Materials Science and Engineering, Stanford University, Stanford, CA, USA;2. Department of Chemistry and Chemical Engineering, Chalmers University of Technology, Gothenburg, Sweden;3. Department of Prosthodontics, Faculty of Odontology, Malmö University, Malmö, Sweden;4. Department of Orthopaedic Surgery, Stanford University, Stanford, CA, USA;5. Department of Oral and Maxillofacial Surgery and Oral Medicine, Faculty of Odontology, Malmö University, Malmö, Sweden;1. Molecular Biology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran;2. Department of Microbiology, School of Medicine, Iran University of Medical Sciences, Iran;3. Department of Bacteriology, Faculty of Medical Sciences, Tarbiat Modares University, Iran;1. Department of Clinical Dentistry, School of Dentistry, Federal University of Espírito Santo, Vitória, Espírito Santo, Brazil;2. Department of Oral Diagnosis, Division of Oral Radiology, Piracicaba Dental School, University of Campinas, Piracicaba, São Paulo, Brazil;3. Department of Oral Radiology, Division of Oral Radiology, School of Dentistry, Federal University of Bahia, Salvador, Bahia, Brazil;1. Department of Endodontics, Faculty of Dentistry, Ain Shams University, Cairo, Egypt;2. Department of Endodontics, Faculty of Dentistry, Future University, Cairo, Egypt;3. Department of Surgery, Anesthesiology and Radiology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt;1. Student, Department of Stomatology, School of Dentistry, University of São Paulo, Brazil;2. Professor, Department of Clinical and Social Dentistry School of Dentistry, Federal University of Paraíba, Brazil;3. Department of Stomatology, School of Dentistry, University of São Paulo, Brazil;4. Professor, Department of Stomatology, School of Dentistry, University of São Paulo, Brazil |
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| Abstract: | Statins are known to stimulate osteoblast activity and bone formation. This study examines whether local application of fluvastatin enhances osteogenesis around titanium implants in vivo. Ten-week-old rats received a vehicle gel (propylene glycol alginate (PGA)) or PGA containing fluvastatin (3, 15, 75 or 300 μg) in their tibiae just before insertion of the implants. For both histological and histomorphometric evaluations undecalcified ground sections were obtained and the bone–implant contact (BIC), peri-implant osteoid volume and mineralized bone volume (MBV) were calculated after 1, 2 and 4 weeks. Using the same models mechanical push-in tests were also performed to evaluate the implant fixation strength. After 1 week the MBV and push-in strength were significantly lower in the 300 μg fluvastatin-treated group than in the other groups (P < 0.01). At 2 weeks, however, the BIC and MBV were both significantly higher in the 75 μg fluvastatin-treated group than in the non-fluvastatin-treated groups (P < 0.01). Similar tendencies were observed at week 4. Furthermore, the data showed a good correlation between the MBV and the push-in strength. These results demonstrate positive effects of locally applied fluvastatin on the bone around titanium implants and suggest that this improvement in osseointegration may be attributed to calcification of the peri-implant bone. |
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