基于“肺与大肠相表里”探讨调节“肠道微生物组”对糖尿病肺损伤的影响＊

“肺与大肠相表里”是中医学理论的基本内容,其核心是肺与大肠作为一个整体而相互关联。近代生物学研究显示：肠道微生态与呼吸道微生态相互影响,肠道微生物组稳态失衡进而导致呼吸道微生态组稳态失衡,即“肠病及肺”,故中医临床往往以“肺肠同治”法进行治疗。西医研究结果显示糖尿病患者往往合并肠道微生物组稳态失衡,而肺作为一个毛细血管密集的脏器,是糖尿病的重要靶器官。因此通过研究近年来的文献资料,结合肠道微生物组这一热点,探讨“肺与大肠相表里”在糖尿病肺损伤中的生物学基础,进而丰富中医藏象理论内涵,为防治糖尿病肺损伤提供新思路。

Intervention of Lung damage in Diabetes from the Regulation of the Gut microbiome Based on the Theory of Exterior and Interior Relation of Lung and Large Intestine

Theory of exterior and interior relation of lung and large intestine is the foundation of traditional Chinese medicine (TCM) theory, and its core theory is to consider lung and large intestine are correlated as whole The imbalance of gut microbiome can induce the imbalance of respiratory tract microbiome, as "large intestinal diseases lead to pulmonary disease", so we can adopt the TCM method to treat the large intestinal and pulmonary disease at the same time. Modern medicine show that the patients with diabetes mellitus often associate with homeostasis imbalance in intestinal microecology group;nevertheless, lungas an organ with rich capillariesis the target organ of diabetes mellitus (DM). Therefore, the biology basis of "theory of exterior and interior relation of lung and large intestine " in diabetic lung injury is discussed by studying recent literature and combining with the heated discussion of intestinal microecology group, so as to enrich the viscera and manifestations theoretical connotation of TCM and provide new ideas for the prevention and treatment of diabetic Pulmonary Injury.