Rat calvaria osteoblast behavior and antibacterial properties of O2 and N2 plasma-implanted biodegradable poly(butylene succinate) |
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| Authors: | Huaiyu Wang Junhui Ji Wei Zhang Wei Wang Yihe Zhang Zhengwei Wu Yumei Zhang Paul K Chu |
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| Institution: | 1. Department of Physics & Materials Science, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, China;2. Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100080, China;3. Department of Prosthodontics, School of Stomatology, Fourth Military Medical University, 145 Changle Xi Road, Xi’an 710032, China;4. School of Materials Science and Technology, China University of Geosciences, Beijing 100083, China;1. Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China;2. Stomatology Department of the General Hospital of Chinese PLA, 28 FuXing Road, Beijing 100853, China;3. Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, Guangdong, China;4. Department of Physics & Materials Science, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, China;1. The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan 430079, PR China;2. Center for Biomedical Materials and Interfaces, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, PR China;3. Faculty of Veterinary Medicine, Zagazig University, Zagazig 44519, Egypt;4. Department of Physics and Department of Materials Science and Engineering, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, China;5. Department of Periodontology, College of Dental Medicine, Nova Southeastern University, Fort Lauderdale, FL 33328, USA;1. Laboratory of Polymer Chemistry and Technology, Department of Chemistry, Aristotle University of Thessaloniki, GR-541 24 Thessaloniki, Macedonia, Greece;2. Institute of Biomaterials, Department of Materials Science and Engineering, University of Erlangen-Nuremberg, Cauerstrasse 6, 91058 Erlangen, Germany;1. Key Laboratory of Artificial Micro- and Nano-Structures of Ministry of Education, School of Physics and Technology, Wuhan University, Wuhan 430072, China;2. The State Key Laboratory Breeding Base of Basic Science of Stomatology, Hubei-MOST & Key Laboratory of Oral Biomedicine of Ministry of Education, Department of Periodontics, School and Hospital of Stomatology, Wuhan University, Wuhan 430079, China;3. Department of Physics and Materials Science, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, China |
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| Abstract: | Poly(butylene succinate), a novel biodegradable aliphatic polyester with excellent processability and mechanical properties, was modified by O2 or N2 plasma immersion ion implantation (PIII). X-ray photoelectron spectroscopy and contact angle measurements were carried out to reveal the surface characteristics of the treated and control specimens. The in vitro effects of the materials on seeded osteoblasts were detected by cell viability assay, alkaline phosphatase activity test, and real-time polymerase chain reaction analysis. Plate counting was performed to investigate the antibacterial properties. Our results show that both PIII treatments significantly improve the hydrophilicity of PBSu, and C O and nitrogen groups (CNH and C NH2) can be detected on the PBSu after O2 and N2 PIII, respectively. The modified samples exhibit similar compatibility to osteoblasts, which is better than that of the control, but O2 PIII and N2 PIII produce different effects according to the osteogenic gene expressions of seeded osteoblasts on the materials. Moreover, the N2 plasma-modified PBSu exhibits anti-infection effects against Staphylococcus aureus and Escherichia coli but no such effects can be achieved after O2 PIII. |
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