丹参对手足口病合并脑炎儿童脑脊液激活素A、S-100B蛋白的影响

目的探讨丹参对手足口病合并脑炎患儿脑脊液激活素A(ACTA)、S-100B蛋白的影响。方法选择2014年8月至2019年7月在我院儿科住院治疗的手足口病合并脑炎患儿76例,随机分为观察组和对照组各38例。对照组给予常规综合治疗,观察组在常规综合治疗基础上加用丹参颗粒口服,连续治疗10 d,比较两组治疗后临床症状消失或减轻时间以及脑脊液ACTA、S-100B水平。结果治疗后观察组意识恢复、惊厥控制、颅内高压的控制优于对照组,观察组脑脊液ACTA、S-100B指标较对照组明显降低,差异有统计学意义(P<0.05)。结论丹参可以改善手足口病合并脑炎的临床症状,降低手足口病合并脑炎的炎症损伤。

Effect of Salvia on ACTA and S-100B protein in CSF of children with HFMD and encephalitis

Objective To investigate the effect of Salvia on ACTA and S-100B protein in CSF of children with HFMD and encephalitis.Methods A total of 76 children with HFMD and encephalitis treated in our hospital from Aug.2014 to July 2019 were divided into two groups:the observation group and the control group.The control group was given routine comprehensive treatment.The treatment group was treated with Salvia on the basis of routine comprehensive treatment.Both groups were treated for 10 days.The clinical effect and the indexes of ACTA and S-100B in CSF of the two groups were compared.Results After treatment,the consciousness recovery,convulsion control and the control of intracranial hypertension in the treatment group were better than those in the control group,and the ACTA and S-100B indexes of CSF in the treatment group were significantly lower than those in the control group(P<0.05).Conclusion Salvia can improve the clinical symptoms of HFMD with encephalitis and reduce the inflammatory damage.