Polymeric micelle-templated synthesis of hydroxyapatite hollow nanoparticles for a drug delivery system |
| |
| Authors: | Feng Ye Haifeng Guo Haijiao Zhang Xiulan He |
| |
| Affiliation: | 1. Department of Composites and Carbon Materials, Institute of Rock Structure and Mechanics, Academy of Sciences of the Czech Republic, Prague 8, Czech Republic;2. Faculty of Mechanical Engineering, Czech Technical University in Prague, Prague 6, Czech Republic;4. Biomedical Centre, Faculty of Medicine in Pilsen, Charles University in Prague, Pilsen, Czech Republic;6. Contipro a.s., R&D Department, Dolni Dobrouc, Czech Republic;9. Institute ofMicrobiology, Faculty of Medicine, Slovak Medical University, Bratislava, Slovakia;1. Marine-Integrated Bionics Research Center, Pukyong National University, Busan 48513 Republic of Korea;2. Department of Biomedical Engineering and Center for Marine-Integrated Biotechnology (BK21 Plus), Pukyong National University, Busan, Republic of Korea;1. School of Materials Science and Engineering, Southwest University of Science and Technology, Mianyang 621010, PR China;2. State Key Laboratory Cultivation Base for Nonmetal Composites and Functional Materials, Southwest University of Science and Technology, Mianyang 621010, PR China;3. College of Mechanics, Taiyuan University of Technology, Taiyuan 030024, PR China;1. Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, 27 Taiping Road, Beijing 100850, China;2. Beijing University of Technology, Beijing 100022, China;3. State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Avenida Padre Tomas Pereira, Taipa, Macao, China;4. Beijing Institute of Technology, Beijing 100081, China;5. Shenyang Pharmaceutical University, Shenyang 110016, China;1. Marine-Integrated Bionics Research Center, Pukyong National University, Republic of Korea;2. Department of Biomedical Engineering and Center for Marine-Integrated Biotechnology (BK21 Plus), Busan 48513, Republic of Korea |
| |
| Abstract: | Hydroxyapatite (HA) hollow nanoparticles (HNPs) have great potential in nanoscaled delivery devices due to their small size, excellent biocompatibility and expected high capacity. However, the preparation of HA HNPs for their application in a drug delivery system has rarely been reported because HA has a complicated crystal structure and it is difficult to obtain stable HA HNPs with hollows that are only nanoscaled in size. In the present study, HA HNPs were successfully produced through a novel polymeric micelle-templating method. The micelles were structured with completely insoluble Pluronic P123 molecules at cloud point as the core and Tween-60 molecules as the shell by the hydrophobic interaction of the alkyl chains with the insoluble P123 core. The morphology of the HA HNPs could be transformed from nanospheres to nanotubes by adding citric acid as a cosurfactant. The prepared HA HNPs had a much higher drug payload than traditional nanoparticles, using vancomycin as the model drug. Most importantly, the HA nanotubes were coupled with a layer of citrate molecules on the HA surfaces, which could further improve the drug load efficiency and could form an excellent pH-controlled open/closed gate for drug release with the addition of cationic polyelectrolytes. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
