T1、T2 mapping成像技术评价蒽环类药物所致心脏毒性的研究进展

随着现代医疗手段的进步,肿瘤患者的生存期逐渐延长,癌症患者的远期生存质量越来越得到重视.蒽环类抗肿瘤药物应用于临床已达半世纪之久,在血液系统肿瘤及乳腺癌的治疗上目前仍然有着不可取代的地位.然而其所导致的心脏毒性亦对肿瘤患者的远期生存构成严重威胁.心脏磁共振(cardiac magnetic resonance,CMR)...

The research progress of T1 and T2 mapping in the evaluation of anthracycline induced cardiotoxicity

With the progress of modern medical means,the survival period of cancer patients is gradually extended,and the long-term quality of life of cancer patients is getting more and more attention.Anthracycline anti-tumor drugs have been used in clinic for half a century,and they still play an irreplaceable role in the treatment of blood system tumors and breast cancer.However,the cardiotoxicity caused by it also poses a serious threat to the long-term survival of cancer patients.Cardiac magnetic resonance(CMR)has become the gold standard for evaluating cardiac function because of its high safety and repeatability.In addition to the conventional indicators of CMR,some emerging indicators that have not been included in ESC guidelines,such as T1 mapping,T2 mapping,etc.,can directly and quantitatively evaluate the degree of myocardial cell edema and fibrosis from the numerical point of view,and give more accurate clinical medication guidance.These emerging technical means have become a research hotspot.In this paper,T1 and T2 mapping are reviewed to evaluate the cardiotoxicity induced by anthracyclines.