| NLRP3炎性小体影响血管衰老的机制及其相关药物的研发 |
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| 引用本文： | 吉晓漫,徐明. NLRP3炎性小体影响血管衰老的机制及其相关药物的研发[J]. 药学学报, 2021, 0(3): 696-702 |
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| 作者姓名： | 吉晓漫 徐明 |
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| 作者单位： | 中国药科大学基础医学与临床药学学院 |
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| 基金项目： | 国家自然科学基金资助项目(81773732)。 |
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| 摘 要： | NOD (nucleotide binding oligomerization domain)样受体家族3(NOD-like receptor protein 3,NLRP3)炎症小体调控天冬氨酸特异蛋白酶-1 (caspase-1)、白细胞介素-18 (interleukin-18,IL-18)和IL-1β等细胞因子...
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| 关 键 词： | NLRP3炎性小体 心脏衰老 血管衰老 心脑血管疾病 抗衰老 senolytics |
The mechanism of NLRP3 inflammasome affecting vascular aging and the development of related drugs |
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| JI Xiao-man,XU Ming. The mechanism of NLRP3 inflammasome affecting vascular aging and the development of related drugs[J]. Acta pharmaceutica Sinica, 2021, 0(3): 696-702 |
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| Authors: | JI Xiao-man XU Ming |
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| Affiliation: | (School of Basic Medicine and Clinical Pharmacy,China Pharmaceutical University,Nanjing 211100,China) |
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| Abstract: | Nucleotide binding oligomerization domain(NOD-like receptor protein 3, NLRP3) inflammasomes regulate the secretion of caspase-1, interleukin-18(IL-18), IL-1β, and other cytokines, and participates in aging.In recent years, it has been found that NLRP3 inflammasomes are abnormally activated in aging heart and vessels,and inhibition of NLRP3 inflammasomes can alleviate heart aging and vascular aging. This review summarizes the research of NLRP3 inflammasome in heart and vascular aging, and the related drugs to promote the discovery of the mechanism of NLRP3 inflammasome in heart and vascular aging and the development of related drugs. |
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| Keywords: | NLRP3 inflammasome heart aging vascular aging cardiovascular and cerebrovascular disease anti-aging senolytics |
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