Influence of Progesterone on Sexual Performance in Male Rats |
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| Authors: | Tathiana A Alvarenga Monica L Andersen Sergio Tufik |
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| Institution: | 1. Department of Anatomical Sciences, School of Medicine, Birjand University of Medical Sciences, Birjand, Iran;2. Department of Anatomy and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran;3. Department of Neurosurgery, School of Medicine, Birjand University of Medical Sciences, Birjand, Iran;4. Department of Public Health, Deputy of Research and Technology, Research Centre of Experimental Medicine, Birjand, Iran;5. Department of Pharmacology, School of Medicine, Birjand University of Medical Sciences, Birjand, Iran;6. Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran;7. Medical Genetic Research Center (MGRC), School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran;8. Cellular & Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran;1. Department of Clinical and Experimental Medicine and Pharmacology, Section of Pharmacology, University of Messina, Messina, Italy;2. Department of Clinical and Experimental Medicine, School and Unit of Allergy and Clinical Immunology, University of Messina, Messina, Italy;3. Pharmaco-Biological Department, University of Messina, Messina, Italy;1. Department of Pharmacy, Urumqi General Hospital of PLA, Urumqi, Xinjiang 830000, China;2. Department Clinical Laboratory, No. 23 Hospital of PLA, Urumqi, Xinjiang 830000, China;3. Department of Chemistry, Fourth Military Medical University, Xi’an, Shanxi 710032, China;1. St. John Hospital and Medical Center, Grosse Pointe, Michigan;2. Henry Ford Hospital, Detroit, Michigan |
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| Abstract: | IntroductionIt has been documented that copulatory experience can alter or improve sexual performance in male rats. However, the hormonal basis and the number of sexual encounters needed for a rat to acquire sufficient performance remains unclear.AimThe aim of this study was to examine whether levels of testosterone and progesterone are associated with sexual performance in male rats.MethodsAdult male Wistar Hannover rats were exposed to a receptive female for 15 minutes every other day for 9 days for acquiring sexual experience.Main Outcome MeasuresAfter training protocol, rats were scored as low or high sexual performers. Hormonal levels (testosterone and progesterone) were evaluated in both trained and non-trained control groups.ResultsOur results showed that a 9-day training period was not sufficient for some male rats to acquire a good level of sexual performance. While 42.5% of the rats displayed excellent sexual performance during the training sessions, 17.5% showed adequate performance, 7.5% had low sexual activity, and 32.5% of the rats did not display any sexual behaviors whatsoever. Additionally, after 4 days of training, rats with excellent/adequate performance showed a significant decrease in ejaculation latency relative to the first day of training. The rats with low or no sexual activity had lower progesterone levels relative to those displaying the highest sexual performance after 9 days of training. Testosterone, in turn, was also significantly reduced in animals with low/no sexual performance compared with excellent/adequate rats.ConclusionIn conclusion, progesterone may be a limiting factor to promoting sexual performance in male rats. Alvarenga TA, Andersen ML, and Tufik S. Influence of progesterone on sexual performance in male rats. |
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