药物基于“肠-脑”通路的研究进展

肠道菌群是由诸多共生及致病微生物组成的复杂而动态的群落,并与宿主紧密合作.近年来,越来越多的证据支持“肠-脑”轴理论,肠道菌群与神经精神疾病之间的联系逐步被发现.由于神经精神疾病治疗药物大多经口服后进入肠道,使得其与肠道菌群可能产生更广泛的相互作用.多项研究表明该类药物可改变肠道菌群的组成和功能,同时肠道菌群也会参与药...

Research progress on the interaction of neuropsychiatric drugs with the gut microbiota

The gut microbiota is an intricate and dynamic community composed of many symbiotic and pathogenic microorganisms, and works closely with the host. In recent years increasing evidence has supported the gut-brain axis theory, lending support for a link between gut microbiota and neuropsychiatric diseases. Since most of the drugs used to treat neuropsychiatric diseases enter the intestinal tract after oral administration, interaction with the gut microbiota is likely. A number of studies have shown that such drugs can change the composition and function of the gut microbiota. At the same time, the gut microbiota also participates in the metabolism of drugs,which in turn have beneficial or harmful effects on brain function. Therefore, the role of gut microbiota in drug metabolism also has attracted attention. This article reviews the research results of the interaction between the two,discusses the influence of neuropsychiatric diseases on the gut microbiota and the effect of the gut microbiota on psychoactive drugs, and provides new ideas for the treatment of various clinical neuropsychiatric diseases.