| 靶向结直肠癌Wnt信号通路的药物研究进展 |
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| 引用本文： | 王与菲,张海婧,吴练秋. 靶向结直肠癌Wnt信号通路的药物研究进展[J]. 药学学报, 2021, 0(3): 689-695 |
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| 作者姓名： | 王与菲 张海婧 吴练秋 |
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| 作者单位： | 中国医学科学院、北京协和医学院药物研究所 |
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| 基金项目： | 国家重大新药创制科技重大专项(2018ZX09711001-002-002,2018ZX09711001-003-001);中央高校基本科研业务费(3332019073);中国医学科学院医学与健康科技创新工程(2016-12M-3-011);天然药物活性物质与功能国家重点实验室开放课题(GTZK201906)。 |
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| 摘 要： | 结直肠癌是胃肠道中常见的恶性肿瘤,临床上具有发病率高和死亡率高的特点.在结直肠癌细胞的胞浆、胞核内常伴有Wnt信号通路中β-catenin等信号分子的异常表达.不同种类的靶向苗头化合物可作用于Wnt信号通路或其上下游相关信号分子,从而抑制或减缓结直肠癌的发生和发展.本文通过对Wnt信号通路成分及Wnt信号通路与结直肠癌...
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| 关 键 词： | 结直肠癌 Wnt信号通路 靶向药物 小分子抑制剂 天然化合物 |
Advances in drug research targeting the Wnt signaling pathway in colorectal cancer |
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| WANG Yu-fei,ZHANG Hai-jing,WU Lian-qiu. Advances in drug research targeting the Wnt signaling pathway in colorectal cancer[J]. Acta pharmaceutica Sinica, 2021, 0(3): 689-695 |
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| Authors: | WANG Yu-fei ZHANG Hai-jing WU Lian-qiu |
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| Affiliation: | (State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China) |
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| Abstract: | Colorectal cancer is a common malignant tumor in the gastrointestinal tract, with the characteristics of high morbidity and mortality. Studies have shown that the occurrence and development of colorectal cancer is closely related to the abnormal activation of Wnt signaling pathway. Abnormal expression of β-catenin in Wnt pathway is found both in the cytoplasm and nucleus of tumor cells. Different drugs can target the Wnt signaling pathway and its upstream and downstream related factors to inhibit or suppress the development of colorectal cancer. We review the components of Wnt signaling pathway, and the correlation between Wnt signaling pathway and colorectal cancer. Then, we summarize the current status of drug research targeting the Wnt signaling pathway in colorectal cancer. Finally, the challenges and prospects of these methods and drugs were briefly summarized. |
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| Keywords: | colorectal cancer Wnt signaling pathway targeted drug small molecule inhibitor natural compound |
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