巴洛沙星对泌尿道病原菌的体外抗菌活性

目的:评价巴洛沙星对泌尿道病原菌的体外抗菌活性。方法:收集泌尿道感染病人尿液中所分离到的249株病原菌,其中革兰阳性菌90株(金黄色葡萄球菌30株、表皮葡萄球菌27株、粪肠球菌18株、B溶血性链球菌15株)、革兰阴性菌159株(大肠埃希菌84株、肺炎克雷伯菌20株、肠杆菌属25株、奇异变形杆菌15株、铜绿假单胞菌15株),采用琼脂二倍稀释法,测定巴洛沙星与左氧氟沙星对该249株泌尿道病原菌的最低抑菌浓度(MIC)。结果:巴洛沙星对革兰阳性菌的MIC_(90)(2～8 mg·L~(-1))是左氧氟沙星MIC_(90)(2～16 mg·L~(-1))的1/4～1/2或相等,对革兰阴性菌的MIC_(90)(4～32 mg·L~(-1))是左氧氟沙星MIC_(90)(2～16 mg·L~(-1))的2～4倍或相等。结论:巴洛沙星对革兰阳性菌和革兰阴性菌均具有抗菌活性,其中对革兰阳性菌的作用稍强于或等于左氧氟沙星,对革兰阴性菌的作用等于或稍弱于左氧氟沙星。

Antibacterial activity of balofloxacin against urinary tract pathogens in vitro

AIM:To evaluate the antibacterial activity of balofloxacin against urinary tract pathogens in vitro.METHODS:Two hundred and forty-nine bacterial tribes were collected from the urine of urinary tract infection patients,including 90 gram-positive bacteria (30 Staphylococcus aureus,27 Staphylococcus epidermidis,18 Enterococcus faecalis,15 Streptococcusβhaemolyticus) and 159 gram-negative bacteria (84 Escherichia coli,20 Klebsiella pneumoniae,25 Enterobacter spp,15 Proteus mirabilis,15 Pseudomonas aeruginosa).The minimum inhibitory concentration (MIC) of balofloxacin and levofloxacin against 249 pathogens of urinary tract infections was determined by agar dilution method.RESULTS:MIC_(90) of balofloxacin (2～8 mg·L~(-1)) was 1/4～1/2 or equal to that of levofloxacin (2～16 mg·L~(-1)) in antagonizing gram-positive bacteria.MIC_(90) of balofloxacin (4～32 mg·L~(-1)) was 2～4 times or equal to that of levofloxacin (2～16 mg·L~(-1)) in treating gram-negative bacteria.CONCLUSION:Balofloxacin possesses antibacterial activity against gram- positive and gram-negative bacteria.Balofloxacin is more powerful than or equal to that of levofloxacin in treating gram-positive bacteria,but less than or equal to that of levofloxacin for gram-negative bacteria.