淮河水中非挥发性有机物的遗传毒性研究

目的:研究淮河水中非挥发性有机物对机体的遗传毒性。方法:采集淮河源水、自来水厂滤池出水、氯化消毒自来水及大型贮水箱水各200 升,经吸附浓缩后予小鼠灌胃染毒。以胸骨骨髓嗜多染红细胞微核率检测致突变性,以精子畸形率检测遗传毒性。结果:淮河源水及消毒处理过的自来水均有一定程度的致突变及致精子畸形性。遗传毒性大小顺序依次为:消毒处理过的自来水> 贮水箱水> 源水> 滤池出水。结论:淮河源水已受到有机诱变物的污染。混凝沉淀具有去除有机物、降低源水遗传毒性作用。而加氯消毒使水质的遗传毒性增高。

STUDIES ON GENOTOXICITY OF NON- VOLATILE ORGANIC CHEMICALSIN HUAI RIVER WATER

Purpose : To study the genotoxicity of non - volatile organic chemicals in Huai river water to organism. Methods : zool of water sample was collecfed f rom Huai river source water、clarified filt ration water 、chlorinated tap water and reservoir’s water , respectively. After being adsorpted and concent rated , water samples were administ rated by gavage into mouse stomach. The mutagenicity was studied by means of micronucleus test in mouse thoracic bone - marrow polychromatic erythrocyte (PCE) and the genotoxicity by means of sperm morphologic analysis. Results : the mutagenicity and sperm deformity of some degree are induced by Huai river source water and tap water. The order of mutagenic potentiality of those samples is as follows : chlouinated tap water > reservoir’s water > source water > clarifying fillration water. Conclusion : The source water is contaminated by organic mutagens. Using coagulation and precipitation , genotoxicity of source water is decreased because of the removal of some mutagenic organic chemicals. Addifionally chlorination can increase the genotoxicity of tap water.