Panton-Valentine Leukocidin-positive methicillin-resistant Staphylococcus aureus lung infection in patients with cystic fibrosis |
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Authors: | Elizur Arnon Orscheln Rachel C Ferkol Thomas W Atkinson Jeffrey J Dunne W Michael Buller Richard S Armstrong Jon R Mardis Elaine R Storch Gregory A Cannon Carolyn L |
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Affiliation: | Department of Pediatrics, Washington University School of Medicine, Campus Box 8116, 660 S Euclid Ave, Saint Louis, MO 63110, USA. Elizur_A@kids.wustl.edu |
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Abstract: | BACKGROUND: Panton-Valentine Leukocidin-expressing (PVL+) methicillin-resistant Staphylococcus aureus (MRSA) is an emerging pathogen worldwide causing fatal necrotizing pneumonias in otherwise healthy individuals but has not been described in patients with cystic fibrosis (CF). Following two cases of patients with CF admitted with lung abscesses in association with PVL+ MRSA, we examined the incidence and the clinical characteristics of MRSA acquisition in our CF patient population. METHODS: Newly acquired MRSA isolates from patients with CF followed up at St. Louis Children's Hospital were analyzed for the presence of Panton-Valentine leukocidin coding region, clindamycin susceptibility, staphylococcal cassette chromosome (SCC) mec type, and multilocus sequence type. Medical records and pulmonary function studies at the time of MRSA isolation were reviewed. RESULTS: MRSA isolates from 40 CF patients were available for analysis. Six children (15%) had PVL+ MRSA infection. All PVL+ organisms were clindamycin susceptible. Patients who acquired a PVL+ organism were more likely to have a focal pulmonary infiltrate on chest radiograph, including cavitary lung lesions in two patients (p = 0.04), a markedly greater decline in FEV1 at the time of MRSA detection (p = 0.01), and a significantly higher WBC count (p = 0.04) and absolute neutrophil count (p = 0.04). These patients were more likely to be admitted for IV antibiotic therapy for respiratory illnesses (p < 0.01). CONCLUSIONS: We describe the emergence of PVL+ MRSA in our CF population in association with development of invasive lung infections including lung abscesses. Early identification and treatment of CF patients with newly acquired PVL+ MRSA may be crucial. |
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Keywords: | cystic fibrosis lung abscess CA-MRSA" },{" #name" :" keyword" ," $" :{" id" :" cekeyw50" }," $$" :[{" #name" :" text" ," $$" :[{" #name" :" __text__" ," _" :" community-acquired methicillin-resistant " },{" #name" :" italic" ," _" :" Staphylococcus aureus CF" },{" #name" :" keyword" ," $" :{" id" :" cekeyw70" }," $$" :[{" #name" :" text" ," _" :" cystic fibrosis HA-MRSA" },{" #name" :" keyword" ," $" :{" id" :" cekeyw90" }," $$" :[{" #name" :" text" ," $$" :[{" #name" :" __text__" ," _" :" hospital-acquired methicillin-resistant " },{" #name" :" italic" ," _" :" Staphylococcus aureus MLST" },{" #name" :" keyword" ," $" :{" id" :" cekeyw110" }," $$" :[{" #name" :" text" ," _" :" multilocus sequence typing MRSA" },{" #name" :" keyword" ," $" :{" id" :" cekeyw130" }," $$" :[{" #name" :" text" ," $$" :[{" #name" :" __text__" ," _" :" methicillin-resistant " },{" #name" :" italic" ," _" :" Staphylococcus aureus MSSA" },{" #name" :" keyword" ," $" :{" id" :" cekeyw150" }," $$" :[{" #name" :" text" ," $$" :[{" #name" :" __text__" ," _" :" methicillin-sensitive " },{" #name" :" italic" ," _" :" Staphylococcus aureus PCR" },{" #name" :" keyword" ," $" :{" id" :" cekeyw170" }," $$" :[{" #name" :" text" ," _" :" polymerase chain reaction PVL" },{" #name" :" keyword" ," $" :{" id" :" cekeyw190" }," $$" :[{" #name" :" text" ," _" :" Panton-Valentine leukocidin Panton-Valentine leukocidin expressing Panton-Valentine leukocidin nonexpressing SCC" },{" #name" :" keyword" ," $" :{" id" :" cekeyw250" }," $$" :[{" #name" :" text" ," _" :" staphylococcal casette chromosome |
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