Clodronate prevents prosthetic migration: A randomized radiostereometric study of 50 total knee patients |
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| Authors: | Maria Hilding Leif Ryd Sören Toksvig-Larsen Per Aspenberg |
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| Institution: | 1. Departments of 1Orthopedics and Center for Clinical Research, Uppsala University, Central Hospital of Vasteras, SE-721 89 Vasteras, Sweden. Tel +46 21 17 30 00. E-mail maria.hilding@ltvastmanland.se;2. 2Orthopedics, Lund University Hospital, SE-221 85, Lund, Sweden. |
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| Abstract: | In a double-blind study, we randomized 50 patients to receive peroral clodronate medication or placebo from 3 weeks before until 6 months after a total knee replacement with a cemented NexGen implant. Migration of the tibial components was measured by radiostereometry at 1 year. Clodronate reduced prosthetic migration, as measured by maximum total point motion, from 0.40 mm to 0.29 mm (p = 0.01). This confirms that the early postoperative migration is related to bone resorption and thus the biology of the bone bed. Since early migration is related to late loosening, 6 months of clodronate medication might reduce the risk of loosening. |
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