早期子宫颈浸润鳞癌组织中环氧合酶-2表达

[目的]探讨早期子宫颈浸润鳞癌组织中环氧合酶-2（cox．2）表达的临床意义。[方法]采用免疫组化EnVision法检测158例子宫颈浸润鳞癌组织和100例正常宫颈组织中COX-2表达。[结果]早期子宫颈鳞癌组织COX．2阳性表达率为55．70％（88／158），明显高于正常宫颈组织（0／100）（x2=84．527，P=-0．000）。单因素分析显示宫颈癌组织COX-2的表达水平与临床分期、宫颈深间质浸润和脉管内瘤栓有关（p〈0．05）；与年龄、淋巴结转移、复发／转移、病理分化程度及肿瘤大小无关（p〉0．05）。[结论]早期子宫颈鳞癌组织COX-2表达阳性者应慎重考虑术后辅助治疗方法。

Expression of Cyclooxygenase-2(COX-2) in Cancer Tissues of Early Stage Invasive Cervical Squamous Cell Carcinoma

[Purpose] To explore the clinical significance of cyclooxygenase-2（COX-2） expression in tumor tissues of 158 cases with early stage cervical squamous cell carcinoma. [Methods] Immunohistochemical assay （EnVision method） was used to detect COX-2 in all speeimens, includ- ing 158 invasive cervical squamous cell carcinoma and 100 normal cervices. [Results] The overall positive expression rate of COX-2 in cervical cancer （55.70%, 88/158） was higher than that in normal cervix（0/100）（X2=84.527 ,P=0.000）. In univariate survival analysis, positive COX- 2 expression related to staging, deep stromal invasion and lymph vascular space involvement （P〈 0.05）. The intensity of expression of COX-2 in cervical cancer did not relate to age, lymph node metastasis, occurrence/metastasis, tumor differentiation and tumor size（P〉0.05）. [Conclusionl Postoperative adjuvant treatment should be considered for the cases of COX-2 positive expres- sion with early stage cervical squamous cell carcinoma.