Zollinger-Ellison Syndrome with Esophagitis and Barrett Mucosa |
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| Authors: | Tom R. Karl M.S. M.D. Frank Pindyck M.D. F.A.C.G. Arthur Sicular M.D. |
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| Affiliation: | Department of Cardiothoracic Surgery, Yale-New Haven Hospital. New Haven. Connection and the Department of Surgery. Huntington Hospital, Huntington. New York, and Mt. Sinai Hospital. New York. New York |
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| Abstract: | Although esophageal disease in Zollinger-Ellison syndrome is being recognized with increasing frequency, Barrett esophagus is seen only rarely. Basal lower esophageal sphincter pressure is probably not different in Zollinger-Ellison syndrome and non-Zollinger-Ellison syndrome patients. Circulating gastrin, therefore, cannot be the major determinant of lower esophageal sphincter pressure in vivo . Total gastrectomy and resection of all metaplastic esophagus, when feasible, is the treatment of choice for patients with Zollinger-Ellison syndrome and Barrett mucosa. |
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