| 对大鼠角膜移植免疫排斥反应的抑制作用 |
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| 引用本文： | 郭金华,查家华,陈国苍. 对大鼠角膜移植免疫排斥反应的抑制作用[J]. 眼科研究, 2001, 19(3): 192-197 |
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| 作者姓名： | 郭金华 查家华 陈国苍 |
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| 作者单位： | 1. 解放军第100医院眼科 苏州,215007
2. 福州总医院眼科 |
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| 摘 要： | 目的
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| 关 键 词： | 角膜移植 |
| 修稿时间： | 0200-07-21 |
The effects of IL-1RA onpenetrating keratoplasty rejection in rat |
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| Guo Jinhua,Zha Jiahua,Chen Guocang. The effects of IL-1RA onpenetrating keratoplasty rejection in rat[J]. Chinese Ophthalmic Research, 2001, 19(3): 192-197 |
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| Authors: | Guo Jinhua Zha Jiahua Chen Guocang |
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| Abstract: | ObjectiveTo study the efficacy of immunosuppressant IL-1RA on the rat model of penetrating keratoplasty.MethodsCorneal transplantation were performed orthotopically from Lou rats to F344 rat's recipients.Animals were randomly assigned to the following groups:1.Control.2.CsA(3mg/kg/2d,subconjunctival injection).3.IL-1RA(0.5mg/kg/2d,subconjunctival injection).Treatment began at the 1st day postoperatively and continued until the 14th day postoperatively.Mean survival times and rejection index were determined.ResultsThe mean survival time of the control group was 12.235±1.674 days,but the mean survival time for CsA and IL-1RA were 17.676±1.528 days and 19.250±1.456 days,respectively,which was statistically significant compared with the control group(P<0.01).Vascularization index in IL-RA group was markedly lower when compared with the control and CsA groups(P<0.01).ConclusionIL-1RA can markedly prolong the survival time of corneal allografts by inhibiting graft rejection,and prevent vascular growth of corneal allografts |
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| Keywords: | keratoplasty graft rejection IL-1R |
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