| 小干涉RNA导入哺乳动物体内的方法与策略研究进展 |
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| 引用本文： | 付爱玲.小干涉RNA导入哺乳动物体内的方法与策略研究进展[J].中国药理学通报,2007,23(2):155-157. |
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| 作者姓名： | 付爱玲 |
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| 作者单位： | 复旦大学神经生物学研究所,上海,200433 |
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| 摘 要： | 小干涉RNA(small interfering RNA,siRNA)是目前研究的比较活跃的一种小RNA。利用siRNA使基因沉寂从而调节目的蛋白的功能,在疾病的基因治疗中有巨大的应用潜力。该文从siRNA在哺乳动物整体水平研究的角度,对近年来siRNA的载体策略以及siRNA导入体内的方法和途径等方面的研究进展作一综述,并讨论了siRNA在体内应用的优势和可能存在的问题。
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| 关 键 词： | siRNA 哺乳动物 输送 载体 |
| 文章编号： | 1001-1978（2007）02-0155-03 |
| 修稿时间： | 2006-09-22 |
Research progress of the methods and atrategies of introducing small interference RNA into mammals |
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| FU Ai-ling.Research progress of the methods and atrategies of introducing small interference RNA into mammals[J].Chinese Pharmacological Bulletin,2007,23(2):155-157. |
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| Authors: | FU Ai-ling |
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| Institution: | Institute of Neurobiology, Fudan University, Shanghai 200433, China |
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| Abstract: | Small interfering RNA (siRNA) is emerging as a powerful tool for in vivo research and for use as potential therapeutic agents. This review demonstrates the examples of the applications of siRNA as a new modality in gene therapy which can elicit down-regulation of gene expression and has prodigious potential in the treatment of diseases in mammals. Before siRNA technique is used in vivo, efficient strategies of delivery must be designed, such as vectors and routes of delivery. The problems that should be considered before applying this technology are outlined. |
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| Keywords: | siRNA |
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