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| 奥硝唑缓释膜的制备及质量控制 | |
| 引用本文： | 徐全臣,王令充,霍光,钟德钰. 奥硝唑缓释膜的制备及质量控制[J]. 中国药师, 2006, 9(5): 434-435 |
| 作者姓名： | 徐全臣 王令充 霍光 钟德钰 |
| 作者单位： | 1. 青岛大学医学院附属医院,青岛,266003 2. 中国海洋大学生命科学院 3. 浙江省中医学院附属新华医院 |
| 摘 要： | 目的:研制以羧甲基壳聚糖为载体的奥硝唑缓释膜并建立质量控制方法。方法:用紫外分光光度法测定药膜中药物含量、均匀度、体外释放度等。结果:在318 nm处测定吸收值,奥硝唑药膜含量均匀,稳定性好;在蒸馏水中10 min释药13．9％,10 h后仍有药物释放。结论:药膜制备工艺简便,质量控制方法准确可靠,该制剂是一种很好的缓释新剂型。 |
| 关 键 词： | 奥硝唑 缓释膜 制备 质量控制 |
| 文章编号： | 1008-049X(2006)05-0434-02 |
| 收稿时间： | 2005-09-08 |
| 修稿时间： | 2005-10-13 |
Preparation and Quality Control of Ornidazole Sustained-Release Membranes |
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| Xu Quanchen,Wang Lingchong,Huo Guang,Zhong Deyu. Preparation and Quality Control of Ornidazole Sustained-Release Membranes[J]. China Pharmacist, 2006, 9(5): 434-435 | |
| Authors: | Xu Quanchen Wang Lingchong Huo Guang Zhong Deyu |
| Affiliation: | Department of Stomatology, Affiliated Hospital of Medical College, Qingdao University, Qingdao266003, P. R. China |
| Abstract: | Objective: To introduce the preparation and quality control methods of the omidazole sustained-release membranes which take CM-chitosan as carriers. Methods: The quantity of omidazole, the uniformity and release rate of omidazole from the membranes were determined by ultraviolet spectrophotometry in vitro. Results: The maximum absorption of omidazole solution was observed at the point of 318 nm wavelength when scanned by the UV-spectrophotometer. And the membrane is uniform and stable. 13.9% omidazole was released from the membrane in the initial 10 minutes and it was still detectable in 10 hours later. Conclusion: The preparation of omidazole sustained-release membrane is simple and convenient. The quality control methods of the membrane are accurate and reliable. |
| Keywords: | Omidazole Sustained-release membrane Preparation Quality control |
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