| 不同促渗剂对盐酸芦氟沙星体外经皮渗透的影响 |
| |
| 引用本文： | 黄齐慧,成明建,冯冠英.不同促渗剂对盐酸芦氟沙星体外经皮渗透的影响[J].河北医药,2004,26(5):400-401. |
| |
| 作者姓名： | 黄齐慧 成明建 冯冠英 |
| |
| 作者单位： | 527300,广东省云浮市人民医院药剂科;527300,广东省云浮市人民医院药剂科;527300,广东省云浮市人民医院药剂科 |
| |
| 摘 要： | 目的 研究几种常用促渗剂对盐酸芦氟沙星体外经皮渗透的影响。方法 用紫外分光光度法检测浓度 ,采用改进Franz扩散池 ,比较几种常用促渗剂对盐酸芦氟沙星渗透系数的影响。结果 1%氮酮和 1%氮酮 10 %丙二醇可显著增大盐酸芦氟沙星的渗透系数 (P <0 .0 1)。结论 1%氮酮和1%氮酮 10 %丙二醇可作为促渗剂用于盐酸芦氟沙星的透皮吸收制剂
|
| 关 键 词： | 盐酸芦氟沙星 1-2丙二醇 月桂氮(艹卓)酮(氮酮) 薄荷醇 油酸 |
Effect of penetration enhancers on skin penetration in vitro of rufloxacin hydrochloride |
| |
| HUANG Qihui,CHENG Mingjian,FENG Guanyin.Yunfu People's Hospital,Guangdong,Yunfu.Effect of penetration enhancers on skin penetration in vitro of rufloxacin hydrochloride[J].Hebei Medical Journal,2004,26(5):400-401. |
| |
| Authors: | HUANG Qihui CHENG Mingjian FENG GuanyinYunfu People's Hospital Guangdong Yunfu |
| |
| Institution: | HUANG Qihui,CHENG Mingjian,FENG Guanyin.Yunfu People's Hospital,Guangdong,Yunfu 527300 |
| |
| Abstract: | Objective To investigate the effects of several penetration enhancers on the skin permeation of rufloxacin hydrochloride.Methods UV Spectrophotometry and improved Franz diffusion cell were used to observe the influence of several penetration enhancers on the permeability coefficient of rufloxacin hydrochloride.Results 1% azone and 1% axone 10% proplylene glycol could obviously enhance the permeability coefficient of rufloxacin hydrochloride.Conclusion 1% azone and 1% azone 10% proplylene glycol are proper penetration enhancers in the transdermic preparation of rufloxacin hydrochloride. |
| |
| Keywords: | rufloxacin hydrochloride propylene glycol azone menthol oleic acid |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
