叶酸和维生素B12治疗某烟厂工人支气管鳞状化生

目的 探讨应用叶酸（FA）和维生素（Vit）B12治疗支气管黏膜重度鳞状化生的可行性。方法 将经痰涂片诊断的56例重度鳞状化生患者随机分为治疗组和对照组，治疗组口服FA和VitB12，持续6个月；对照组服用安慰剂治疗6个月，治疗前、后检测血清FA、VitB12浓度。细胞学异型程度用0～3的等级表示。结果 两组在治疗前的细胞异型程度均为3，血清FA、VitB12浓度比较差异无显著性；治疗后治疗组细胞异型程度均值为1．22，治疗前后比较差异有显著性（P〈0．05），而对照组均值为2．4，治疗前后比较差异无显著性。血清FA、VitB12浓度也有类似结果。结论 FA和VitB12对鳞状化生有治疗作用。

A study on folic acid and Vit B12 in the treatment of bronchial squamous metaplasia in a cigarette factory

Objective To elucidate the possibility of treating severe bronchial squamous metaplasia with FA and Vit B_ 12 . Methods 56 cases of severe bronchial squamous metaplasia identified using sputum smear were randomly divided into two groups . FA 15mg and Vit B_ 12 1.5 mg were administered daily for 6 months for the trial group, while the other used placeboes. The grade of cellular atypia was measured on sputum smear using a scoring system from 0 to 3. Results There were no significant differences between two groups in the scores and the serum FA,Vit B_ 12 at the beginning. The trial group showed significant decrease of the scores, increase of the serum FA, Vit B_ 12 , while the control group did not, which showed statistical difference (P<0.05). Conclusion Bronchial squamous metaplasia could be treated with FA and Vit B_ 12 .