补阳还五汤治疗缺血性中风急性期随机对照试验的系统评价研究

目的：系统评价补阳还五汤治疗缺血性中风急性期的疗效及安全性。方法：检索补阳还五汤治疗缺血性中风急性期的随机对照试验文献，筛选合格研究，应用Jadad评分法进行质量评价，运用异质性检验、Meta-分析、敏感性分析、漏斗图分析等方法统计相关数据。结果：纳入22项研究，Jadad评分所有研究得分均低于3分，属低质量文献。Meta-分析结果显示，补阳还五汤治疗缺血性中风急性期总有效率比较的RR（99％CI）为1．19（1．10，1．30），神经功能缺损评分比较的WMD（99％CI）为-2．20（-3．48，-0．91）。结论：补阳还五汤对缺血性中风急性期患者有效，且安全性较高。纳入研究质量低等因素在不同程度影响了上述结论的可靠性，要进一步验证补阳还五汤治疗缺血性中风急性期的疗效及安全性，尚需进行设计合理、执行严格、多中心大样本且随访时间足够的随机对照试验。

A Systematic Review on the Decoction in Nigorating Yang for Recuperation for Acute Ischaemic Stroke

Objective:To vealuate efficacy and safety of decoction in Nigorating yang for recuperation for acute ischaemic stroke.Methods: Randomized controlled trails(RCTs)of decoction in Nigorating yang for recuperation for acute ischaemic stroke were identified,eligible studies were included,the methodological quality of inclusive trails was assessed by Jadad scale.Heterogeneity test,Meta-analysis,funnel plot analysis and sensitivity analysis were used to analyse data.Results:Twenty-two RCTs were included,with all trails of low methodological quality,and decoction in Nigorating yang for recuperation no-treatment control,Meta-analysis indicated that RR of overall effective rate was 1.1999% CI(1.10,1.30)],weighted mean difference of improving neurological impairment was-2.2099% CI(-3.84,-0.91)].Conclusion:This systematic review showed that decoction in Nigorating yang for recupera tion is effective and safety for acute ischaemic stroke.However,the evidence is not strong due to the general low methodological quality.To determinately evaluate efficacy and safety of decoction in Nigorating yang for recuperation for acute ischaemic stroke,more rationally designed and strictly executed RCTs with large samples are necessary.