Matrix metalloproteinases in inflammatory myopathies: enhanced immunoreactivity near atrophic myofibers |
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Authors: | Schoser B G H Blottner D Stuerenburg H-J |
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Institution: | Friedrich-Baur-Institute, Department of Neurology, Ludwig-Maximillians University Munich, Munich, Germany. benedikt.schoser@fbs.med.uni-muenchen.de |
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Abstract: | OBJECTIVES: To further examine the role of proteolytic enzyme expression of matrix metalloproteinases (MMP) and T-cell markers in inflammatory myopathies and controls. MATERIAL AND METHODS: We studied the expression of MMP-2, MMP-7, and MMP-9 in 19 cases of inflammatory myopathies and controls using immunocytochemistry. RESULTS: Inflammatory myopathies showed distinct patterns of up-regulation of MMP. MMP-9 was strongly expressed in atrophic myofibers in all inflammatory myopathies. MMP-2 immunoreactivity was similar in its distribution, however, to a weaker intensity. In dermatomyositis the perifascicular atrophy showed pronounced MMP-9 immunoreactivity, probably reflecting denervated patterns of myofibers. Moreover, MMP-7 strongly immunolabeled invaded myofibers in polymyositis cases only. CONCLUSION: These patterns confirm, that MMP-7 up-regulation is prominent in PM, while MMP-2 immunoreactivity is only slightly elevated in inflamed muscle. In general, MMP-9 up-regulation appears to be an important additional molecular event in the multistep process of all inflammatory myopathies. |
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Keywords: | matrix metalloproteinases extracellular matrix myositis inflammation |
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