Synthesis and antioxidant activity of substituted-1,3,2-diazaphosphole 1-oxides |
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Authors: | Naidu Kalla Reddi Mohan Rao Pasupuleti Visweswara Raju Chamarthi Naga Srinivasulu Kambam |
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Affiliation: | Department of Chemistry, Sri Venkateswara University, Tirupati, India. |
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Abstract: | Synthesis of 1-substituted-1,3,2-diazaphosphole 1-oxides (3a-l) were accomplished via a two-step process. It involves the preparation of diazaphospholo 1-oxide monochloride intermediate (2) and its subsequent reaction with phenols/amino acid esters in dry THF in the presence of triethylamine at 40-45°C. The structures of newly synthesized compounds were characterized by spectral and elemental analysis. The title compounds were evaluated for their in-vitro antioxidant properties. |
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Keywords: | Antioxidant activity 1,3,2‐Diazaphosphole 2‐oxides |
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