Cem-Ostetic/rhBMP-2复合物促进即刻种植体周围骨组织再生的研究

目的：研究Cem-Ostetic/rhBMP-2对即刻种植骨缺损修复的生物学特性。方法：将6只狗随即分成2组,拔除犬双侧下颌第二、三、四前磨牙,即刻植入种植体,每个种植体颊侧制备标准缺损,分别植入Cem-Ostetic/rhBMP-2、Cem-Ostetic、自体骨。术后6、12周分期处死,进行大体、影像学、组织学观测。结果：术后6、12周各组均有不同程度的骨组织再生。各个时期观察显示Cem-Ostetic/rhBMP-2组新生骨与种植体间的骨结合较其他组多。结论：Cem-Ostetic/rhBMP-2能有效促进种植体周围骨缺损修复,并促进种植体-骨界面形成较完善的骨整合。

Study on Cem-Ostetic/rhBMP-2 Complex to Promote Bone Regeneration around Immediate Implants

Objective：To study the biologic effects of Cem-Ostetic/BMP-2 in rehabilitating bone defects during immediate implantation.Methods：Six dogs were divided into two groups randomly.We extracted each dog mandibular second third and fourth premolars to create edentulous regions.Immediate implantation was placed in the medial root site.Standard bone defects were prepared on the buccal side of the implants.The defects were filled with a composite consisting of Cem-Ostetic/rhBMP-2,autologous bone graft and pure Cem-Ostetic.At 6 weeks and 12 weeks postoperative,the dogs were sacrificed for clinical check,radiological,and histological analysis.Results：At 6,12 weeks,various amount of new bone appeared in each group.Each time observation demonstrated that Cem-Ostetic/BMP-2 group had more new bone and osseointegration than the other groups.Conclusion：The Cem-Ostetic/rhBMP-2 composite can effectively accelerate the reconstruction of peri-implant bone defects and improve the osseointegration at the interface between the implant and bone.