CD44v6在口腔鳞状细胞癌中的表达 |
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引用本文: | 张瑞敏,吕凡,穆森,谢晓华,张梅兮,赵晨,常靓.CD44v6在口腔鳞状细胞癌中的表达[J].口腔医学研究,2011,27(9):790-793. |
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作者姓名: | 张瑞敏 吕凡 穆森 谢晓华 张梅兮 赵晨 常靓 |
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作者单位: | 1. 哈尔滨医科大学附属第二医院牙周黏膜科 黑龙江哈尔滨 150086 2. 北京世纪坛医院口腔科 |
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基金项目: | 黑龙江省自然科学基金,黑龙江省教育厅科学技术研究项目 |
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摘 要: | 目的:研究细胞粘附分子CD44v6在口腔鳞状细胞癌中的表达及其与临床参数的关系。方法:采用免疫组织化学S-P法对49例附有癌旁组织的口腔鳞状细胞癌及其中的7例转移淋巴结进行CD44v6的检测。结果:CD44v6表达与肿瘤病理分级有关(P〈0.05),随着肿瘤分化程度的降低,CD44v6表达呈降低趋势,部分区域甚至不表达;发生淋巴结转移组与未发生淋巴结转移组的原发灶比较,CD44v6表达强度有显著差异(P〈0.01),发生淋巴结转移组的原发灶CD44v6高表达,未发生淋巴结转移组的原发灶CD44v6低表达。结论:CD44v6的表达与口腔鳞状细胞癌的分化程度有一定相关性;CD44v6高表达有可能作为口腔鳞状细胞癌淋巴转移的一个预测指标。
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关 键 词: | CD44v6 鳞状细胞癌 分化程度 淋巴结转移 |
Expression of CD44v6 in Human Oral Squamous Cell Carcinoma. |
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Institution: | ZHANG Rui-min,LV Fan,MU Sen,et al.Department of Periodontology and Oral Mucosa,The Affiliated Second Hospital,Haerbin Medical University.Haerbin 150086 |
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Abstract: | Objective: To investigated the expression of CD44v6 in human oral squamous cell carcinoma(OSCC) and the relationship between their expressions and the clinical datum.Methods: 49 cases of OSCC including their tumor margin and 7 metastatic lymph nodes were studied by immunohistochemical S-P method.Results: The expression of CD44v6 correlated with histological differentiation(P0.05).The trend of the expression was down-regulated with the poorly differentiated carcinoma.There was even no expression in some area.OSCC with metastatic lymph node displayed significant up regulation of CD44v6 than those without(P0.01).Conclusion: The expression of CD44v6 might be relevent to the differentiation of OSCC.Higher expression of CD44v6 might play a role in the metastasis of OSCC and might be used as a useful diagnostic tool to determine the metastatic potential of OSCC to lymph node. |
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Keywords: | CD44v6 Oral squamous cell carcinoma Grade Lymphatic metastasis |
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