RPDs基托材料对口腔念珠菌定植的影响

目的：初步研究可摘局部义齿（RPDs）不同基托材料对口腔念珠菌的定植的影响。方法：临床随机选择RPDs修复患者147例。其中树脂基托义齿（A组）58例,钴铬合金铸造基托义齿（B组）63例,纯钛及钛合金铸造基托义齿（C组）26例。吐唾法取样,用CHROMagar培养基鉴定念珠菌菌种。培养基中念珠菌菌落计数为每个样本的念珠菌检出强度。通过统计学方法,比较3组不同基托材料义齿戴用人群念珠菌检出率和检出强度的差异。结果：147例不同基托材料义齿戴用人群中检出的念珠菌包括白色念珠菌、热带念珠菌、克柔念珠菌3个菌种。A、B、C组白色念珠菌和非白色念珠菌检出率无显著差异。白色念珠菌的菌落形成单位数,A组显著高于B、C组（P〈0.05）;B组显著高于C组（P〈0.05）。非白色念珠菌间的菌落形成单位数无明显差异。结论：戴不同材料义齿患者口腔除了能检出白色念珠菌,还可检出非白色念珠菌;口腔念珠菌的菌落形成单位数与义齿基托材料密切相关,钛及钛合金基托义齿应为预防义齿性口炎的首选义齿。

Oral Candidal Colonization in the Patients with RPDs by Different Base Materials

Objective：To study of the oral Candidal colonization status with different base-materials denture.Methods：147 cases who wear RPDs were divided into three groups：group A（resin base denture）,group B（Co-Cr alloy base denture）,and group C（Titanium and Titanium alloy base denture）.Non-stimulated saliva were collected by standard procedure as before.Salivary samples were inoculated on CHROMagar CandidaTM to identify Candida strains.The total number of colonies was considered as the detectable intensity of oral Candida.Statistical analysis was used to compare the differences of detection rate and detection intensity between three denture materials.Results：Candida was isolated from 147 cases who wear different base materials denture,such as Candida albicans,Candida tropical,Candida krusei.The frequency of Candida showed no difference between group A,B,and C.The Candida albicans CFU count was significantly higher in group A than in group B and C（P0.05） and group B was significantly higher than group C（P0.05）.The non-Candida albicans CFU count showed no difference between three groups.Conclusion：Three strains of Candida albicans,Candida tropicalis,Candida krusei can be detected in people who wear different base material dentures.CFU count of oral candidiasis are closely related to the use of denture base materials,titanium and titanium base alloy denture are the best choice to prevent denture stomatitis.