| 小鼠急性重复缺氧对脑神经节苷脂的影响 |
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| 引用本文： | 潘颖,杨典洱.小鼠急性重复缺氧对脑神经节苷脂的影响[J].首都医学院学报,1998,19(1):9-12. |
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| 作者姓名： | 潘颖 杨典洱 |
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| 作者单位： | 首都医科大学生物化学教研室 |
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| 摘 要： | 利用重复缺氧的方法，研究小鼠间歇性低氧适应和神经节苷脂（Ｇｌｓ）的作用。发现：在小鼠急性缺氧时，血液和脑组织中的谷胱甘肽过氧化物酶（ＧＳＨｐｘ）活性明显下降（Ｐ＜０．０１）；脑组织中的ＧＳＨｐｘ活性在急性重复缺氧时较１次缺氧时升高（Ｐ＜０．０５）；脑组织的Ｇｌｓ含量明显下降（Ｐ＜０．０１）。提示Ｇｌｓ和ＧＳＨｐｘ有相同的抗自由基活性。急性重复性缺氧时Ｇｌｓ下降，去甲肾上腺素（ＮＥ）也下降（Ｐ＜０．０１），不同于持续性低氧的表现。推测脑细胞β受体 腺苷酸环化酶系统在急性重复缺氧时未受严重伤害，Ｇｌｓ和缺氧、缺氧保护有关。
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| 关 键 词： | 急性缺氧 重复缺氧 神经节苷脂 谷胱甘肽过氧化物酶 血糖 |
| 收稿时间： | 1997-04-03 |
The Effect of Gangliosides and Animal Protecting Effect in Acute and Repetitive Hypoxia |
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| Pan Ying,Yang Dian'er,Yu Peilan.The Effect of Gangliosides and Animal Protecting Effect in Acute and Repetitive Hypoxia[J].Journal of Capital University of Medical Sciences,1998,19(1):9-12. |
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| Authors: | Pan Ying Yang Dian'er Yu Peilan |
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| Institution: | Department of Biochem, Capital University of Medical Sciences |
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| Abstract: | Repetitive hypoxia method was used to study the adaptation of mice to intermittent hypoxia and the effect of gangliosides. The activity of GSHpx was decreased(P<0.01), not only in blood but also in brain. Under acute repetitive hypoxia for 4 times, the activity of GSHpx in brain was increased(P<0.05)as compared with that under the hypoxia for one time. At that time, the gangliosides in the membrane of brain cell were decreased(P<0.01). It showed that Gls and the activity of GSHpx were interrelated. The contents of norepinephrine in brain were lower than the controls(P<0.01). The results indicated that the system of β receptor adenyl cyclase was not injured by acute and repetitive hypoxia. |
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| Keywords: | acute hypoxia repetitive hypoxia gangliosides glutathione peroxidase blood sugar |
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