辛伐他汀对高血压病患者血清炎症因子水平的影响

目的研究辛伐他汀对高血压病患者血清高敏c反应蛋白（high-sensitivity C reactive protein．hs-CRP）和肿瘤坏死因子（tumour necrosis factor-α，TNFα）水平的影响。方法1、2期高血压病105例，口服硝苯地平缓释片10mg每日2次，对照组为25名健康者；硝苯地平组35例，仅给硝苯地平；辛伐他汀1组36例，加用辛伐他汀20mg；辛伐他汀2组34例，加用辛伐他汀40mg。每疗程30d。观察治疗前后血压、血脂、hs—CRP和TNFα。结果高血压病患者血清hs—CRP和TNFα明显高于健康者（P〈0．05）；治疗1个月后，与硝苯地平组比较，辛伐他汀1组和辛伐他汀2组治疗后hs—CRP、TNFα皆有明显下降（P〈0．05），辛伐他汀2组改变尤为明显（P〈0．01）；3组血压下降幅度近似。结论高血压病患者血清hs-CRP、TNFα水平增高，辛伐他汀治疗使之降低，提示该作用独立于其降脂作用之外。

Effects of simvastatin on serum inflammatory factors in patients with hypertension

Objectives To study the effects of simvastatin on serum high-sensitivity C-reactive protein （hs- CRP） and tumor necrosis factor-α （TNFot） in patients with hypertension. Methods One hundred and five patients with hypertension （grade 1 or grade 2） were randomly divided into the three groups. Thirty-five patients in the group A were given nifedipine SR 10 mg twice daily for 30 days, 36 patients in the group B were given nifedipine SR 10 mg twice daily and simvastatin 20 mg once daily for 30 days, 34 patients in the group C were given nifedipine SR 10 mg twice daily and simvastatin 40 mg once daily for 30 days. Twenty-five healthy subjects were used as control group. Before and after treatment, blood pressure （BP） were observed, blood lipids were measured and serum hs-CRP and TNFα were determined by radioimmunoassay （RIA） or ELISA. Results The serum levels of hs-CRP and TNFot in the patients with hypertension were significantly higher than those in the control group （P〈0.05） ; The serum levels of hs-CRP and TNFα were significantly lower after 30 days of therapy in the two groups treated by simvastatin （P〈0.01） , especially in the 40 mg simvastatin group, while no significant difference was observed before and after treatment in the routine nifedipine SR therapy group （P〉 0.05）, and the BP in three groups were similarly reduced. Conclusions The serum levels of hs-CRP and TNFα are increased in patients with hypertension and simvastatin may decrease dose-dependently the serum levels of hs-CRP and TNFα. The anti-inflammatory effect of simvastatin may be beyond that lipid lowering.