| 人皮肤T细胞淋巴瘤系Hut-78细胞FHIT基因缺失的研究 |
| |
| 引用本文： | 田中伟,宋向凤,彭振辉. 人皮肤T细胞淋巴瘤系Hut-78细胞FHIT基因缺失的研究[J]. 中国皮肤性病学杂志, 2003, 17(5): 289-290 |
| |
| 作者姓名： | 田中伟 宋向凤 彭振辉 |
| |
| 作者单位： | 1. 西安交通大学第二医院皮肤科,陕西,西安,710004
2. 新乡医学院免疫学教研室,河南,新乡,453000 |
| |
| 摘 要： | 目的 探讨抑癌基因FHIT在Hut 78细胞中的缺失情况。方法 用巢式RT PCR方法研究FHIT的缺失情况。结果 Hut 78细胞中FHIT基因mRNA比正常缩短 ,外显子 5丢失。结论 FHIT基因外显子 5的缺失可能是皮肤T细胞淋巴瘤FHIT基因失活的主要方式 ,在皮肤淋巴瘤的发生中占有重要地位
|
| 关 键 词： | FHIT基因 皮肤T细胞淋巴瘤 |
| 文章编号： | 1001-7089(2003)05-0289-02 |
| 修稿时间： | 2002-10-17 |
The Study of the Loss of FHIT Gene in Cutaneous T Cell Lymphomas Hut-78 Cell |
| |
| TIAN Zhong-wei,SONG Xiang-feng,PENG Zhen-hui. The Study of the Loss of FHIT Gene in Cutaneous T Cell Lymphomas Hut-78 Cell[J]. The Chinese Journal of Dermatovenereology, 2003, 17(5): 289-290 |
| |
| Authors: | TIAN Zhong-wei SONG Xiang-feng PENG Zhen-hui |
| |
| Abstract: | ObjectiveTo investigate the loss patterns of FHIT gene,a tumor suppressor gene,in the Hut-78 cells.MethodsNested RT-PCR was used to amplify the whole leng th of mRNA.ResultsThe mRNA of FHIT gene declined signifi cantly in Hut-78 cell in comparison with the normal lymphocytes,exon-5 of FHIT gene was lost. ConclusionThe loss of exon-5 may be one of the major in activation patterns of FHIT gene in cutaneous T cell lymphomas,which may have v ery important role in the pathogenesis of cutaneous T cell lymphomas. |
| |
| Keywords: | FHIT gene Cutaneous T cell lymphoma |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
