Dextrose prolotherapy for pain and dysfunction of the TMJ reducible disc displacement: A randomized,double-blind clinical study |
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| Institution: | 1. A.R.M. Center of Otolaryngology Head and Neck Surgery, Assuta Medical Centers, Tel Aviv, Israel. Affiliated with Ben-Gurion University of the Negev, Israel;2. Department of Academy and Research, Assuta Medical Centers, Tel Aviv, Israel;1. Unit of Maxillofacial and Plastic Surgery, APHP, Necker-Enfants Malades, 149 Rue de Sèvres, Paris, 75015, France;2. Unit of Maxillofacial Surgery, APHP Pitié-Salpetrière Hospital, Pierre et Marie Curie University, Sorbonne University, Paris, 75013, France;3. Department of Head and Neck Surgical Oncology, Gustave Roussy Cancer Campus, 114 Rue Edouard Vaillant, Villejuif, 94800, France;4. Department of Pathology, APHP, Necker Enfants Malades, 149 Rue de Sèvres, Paris, 75015, France;5. University Paris Descartes, 12 Rue de l''École de Médecine, 75006, Paris, France;6. Department of Biostatistics, Gustave Roussy Cancer Campus, 114 Rue Edouard Vaillant, Villejuif, 94800, France;7. Radiation Oncology Department, Gustave Roussy Cancer Campus, 114 Rue Edouard Vaillant, Villejuif, 94800, France;8. Department of Pediatric Radiology, APHP, Necker Enfants Malades, 149 Rue de Sèvres, Paris, 75015, France;9. Plastic and Reconstructive Surgery Department, Gustave Roussy Cancer Campus, 114 Rue Edouard Vaillant, Villejuif, 94800, France;10. Department of Radiology, Gustave Roussy Cancer Campus, 114 Rue Edouard Vaillant, Villejuif, 94800, France;11. Unit of Otolaryngology and Head and Neck Surgery, APHP, Necker Enfants Malades, 149 Rue de Sèvres, Paris, 75015, France;12. Methodology and Biostatistics Unit, Centre Oscar Lambret, 3 Rue Frederic Combemale, Lille, 59000, France;13. CESP, INSERM, Paris-Sud, Paris-Saclay University, Villejuif, 94805, France;14. Department of Clinical Studies, Unicancer, 101 Rue de Tolbiac, 75654, 13 Paris cedex, France;15. Department of Oncology for Children and Adolescents, Gustave Roussy Cancer Campus, 114 Rue Edouard Vaillant, Villejuif, 94800, France;1. Division of Plastic and Reconstructive Surgery, Yale School of Medicine, New Haven, CT, USA;2. Division of Plastic and Reconstructive Surgery, Mayo Clinic Florida, Jacksonville, FL, USA;3. Department of Plastic Surgery, University of São Paulo, São Paulo, Brazil;1. University Hospital Augsburg, Department of Otolaryngology, Head and Neck Surgery, Stenglinstrasse 2, 86156, Augsburg, Germany;2. Institute of Mathematics, University of Augsburg, Universitätsstrasse 2, 86159, Augsburg, Germany;1. Division of Oral and Maxillofacial Surgery, Department of Disease Management Dentistry, Tohoku University Graduate School of Dentistry, 4–1 Seiryo-machi, Aoba-ku, Sendai, 980-8575, Miyagi, Japan;2. Joint Research Department of Next-Generation Dental Materials Engineering, Tohoku University Graduate School of Dentistry, 4–1 Seiryo-machi, Aoba-ku, Sendai, 980-8575, Miyagi, Japan;3. Division of Advanced Prosthetic Dentistry, Tohoku University Graduate School of Dentistry, 4–1 Seiryo-machi, Aoba-ku, Sendai, 980-8575, Miyagi, Japan |
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| Abstract: | To assess the efficacy of dextrose prolotherapy on the clinical signs and symptoms of patients having disc displacement with reduction (DDWR).This prospective, randomized, double-blind clinical study included thirty patients suffering from bilateral DDWR. The patients were randomly divided into two equal groups. After induction of local anesthesia, each joint was injected in two sites; one in the superior joint space and the other in the retrodiscal tissue, using 25% dextrose solution in group I and normal saline in group II. Pain intensity, maximal interincisal opening (MIO), and joint sounds (JS) were evaluated preoperatively, 1 week after each injection, and 3 months and 6 months after the last injection.Patients in group I showed significant improvement in pain and MIO, and higher satisfaction with treatment than patients in group II. Compared to saline injection, dextrose injection resulted in an improvement in JS but without significant difference within and between groups.Intra-articular injection of 25% dextrose is effective in the treatment of pain and dysfunction of TMJ DDWR as shown by significant improvement in pain and MIO and patient satisfaction. The technique is simple, easy to do, safe and should be adopted whenever appropriate. |
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| Keywords: | Dextrose prolotherapy Disc displacement with reduction Joint sounds Temporomandibular joint Temporomandibular disorders |
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