| Effect of Coiquhoumia Root on the Expression of Transforming Growth Factor-β in Mesangiai Proliferation Giomerulonephritis Model |
| |
| 引用本文： | 曾红兵,常伟.Effect of Coiquhoumia Root on the Expression of Transforming Growth Factor-β in Mesangiai Proliferation Giomerulonephritis Model[J].华中科技大学学报(医学英德文版),2005,25(4):412-415. |
| |
| 作者姓名： | 曾红兵 常伟 |
| |
| 作者单位： | [1]Department of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong Universityof Science and Technology, Wuhan 430030, China |
| |
| 摘 要： | Summary： To study the efficacy and the mechanism of Colquhoumia root （ Tripterygium hypoglaucure （Le,vL） Hutch） in the treatment of mesangial proliferation glomerulonephritis （MsPGN）, SD rats were injected with anti-thymoeyte serum （ATS） to make MsPGN model （anti-Thyl model）. The rats were then divided into 3 groups： normal control group, anti-Thyl model group and treatment group. Histopathologieal （HE, PAS）, immunohistoehemieal, RT-PCR technique and computer imaging analysis system were used to evaluate mesangial matrix production, the expression of TGF-β protein and mRNA in the tissues of kidney. Our result showed that proteinuria and the ratio of extraeellular matrix/glomerular capillaries area （ECM/CA） were increased significantly in model group. The expression of both TGF-β protein and mRNA in glomeruli was much higher in model group than in control group （P〈0.01）. After the treatment with Colquhoumia root, proteinuria, ECM/CA and the expression of both TGF-β1 protein and mRNA in glomeruli were significantly decreased in treatment group as compared with those in model group. It is concluded that Colquhoumia root is effective in reducing proteinuria and mesangial matrix proliferation in MsPGN and it may achieve these effects by inhibiting the expressions of TGF-β1 protein and mRNA of mesangial cells.
|
| 关 键 词： | 转换生长因子-β 细胞增生 血管球性肾炎 蛋白尿 |
| 收稿时间： | 2005-01-21 |
Effect of colquhoumia root on the expression of transforming growth factor-β in mesangial proliferation glomerulonephritis model |
| |
| Zeng Hongbing,Chang Wei.Effect of colquhoumia root on the expression of transforming growth factor-β in mesangial proliferation glomerulonephritis model[J].Journal of Zuazhong University of Science and Technology: Medical Edition,2005,25(4):412-415. |
| |
| Authors: | Zeng Hongbing Chang Wei |
| |
| Institution: | (1) Department of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030 Wuhan, China |
| |
| Abstract: | Summary To study the efficacy and the mechanism of colquhoumia root (Tripterygium hypoglaucum (Le, vL)Hutch) in the treatment of mesangial proliferation glomerulonephritis (MsPGN), SD rats were injected with anti-thymocyte serum
(ATS) to make MsPGN model (anti-Thy1 model). The rats were then divided into 3 groups: normal control group, anti-Thy1 model
group and treatment group. Histopathological (HE, PAS), immunohistochemical, RT-PCR technique and computer imaging analysis
system were used to evaluate mesangial matrix production, the expression of TGF-β1 protein and mRNA in the tissues of kidney. Our result showed that proteinuria and the ratio of extracellular matrix/glomerular
capillaries are (ECM/CA) were increased significantly in model group. The expression of both TGF-β1 protein and mRNA in glomeruli was much higher in model group than in control group (P<0.01). After the treatment with Colquhoumia root, proteinuria, ECM/CA and the expression of both TGF-β: protein and mRNA in glomeruli were significantly decreased in treatment group as compared with those in model group. It is
concluded that Colquhoumia root is effective in reducing proteinuria and mesangial matrix proliferation in MsPGN and it may
achieve these effects by inhibiting the expressions of TGF-β1 protein and mRNA of mesangial cells.
ZENG Hongbing, female, born in 1966. Associate Professor |
| |
| Keywords: | mesangial proliferation glomerulonephritis Colquhoumia root tripterygium hypoglaucum (Le vL)Hutch transforming growth TGF-β 1 |
| 本文献已被 维普 SpringerLink 等数据库收录！ |
|
