| 尿浊清治疗微小病变肾病的实验研究 |
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| 引用本文： | 李焕宇,邓虹珠,王彩云. 尿浊清治疗微小病变肾病的实验研究[J]. 中药材, 2004, 27(6): 430-432 |
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| 作者姓名： | 李焕宇 邓虹珠 王彩云 |
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| 作者单位： | 1. 解放军广州疗养院,广州,510515
2. 第一军医大学中医系,广州,510515 |
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| 摘 要： | 目的:研究尿浊清对微小病变肾病(MCN)的治疗作用.方法:利用尾静脉注射阿霉素复制大鼠微小病变肾病模型.观察中药尿浊清对MCN大鼠24 h尿蛋白、血清蛋白、脂质代谢、血清超氧化物歧化酶(SOD)活性、丙二醛(MDA)含量及肾脏组织病理学变化的影响.结果:尿浊清可减少蛋白尿,提高血清总蛋白、白蛋白及SOD活性,降低血清胆固醇、甘油三酯及MDA含量,并可促进肾小球病理改变的修复.结论:尿浊清是治疗MCN的有效方剂,其机理可能与清除氧自由基,抑制脂质过氧化反应的作用有关.
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| 关 键 词： | 尿浊清 微小病变型肾病 脂质过氧化反应 |
| 修稿时间： | 2004-02-26 |
Experimental Study on Treatment of Minimal Change Nephropathy with Niaozhuoqing |
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| Li Huanyu ,Deng Hongzhu ,Wang Caiyun. Experimental Study on Treatment of Minimal Change Nephropathy with Niaozhuoqing[J]. Journal of Chinese medicinal materials, 2004, 27(6): 430-432 |
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| Authors: | Li Huanyu Deng Hongzhu Wang Caiyun |
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| Affiliation: | Guangzhou Sanatorium of PLA, Guangzhou 510515. |
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| Abstract: | Objective: To study the therapeutic effect of Niaozhuoqing on minimal change nephropathy(MCN) in rats. Methods: The MCN rat model was induced by intravenous injection of adriamycin. The effect of treatment on 24h urine protein, serum protein, lipid metabolism, malondialdehyde (MDA),superoxide dismutase(SOD) in serum, and renal histopathological changes were observed. Results: Niaozhuoqing could decrease the contents of proteinuria, blood lipid and MDA in serum, increase serum protein, SOD level and pathologically restore the glomeruli. Conclusion: Niaozhuoqing has good effects on MCN, which probably related to decrease serum lipids level and reduce oxygen free radicals. |
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| Keywords: | Niaozhuoqing Minimal change nephropathy Lipid peroxid |
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