| 前胡香豆素A的分离和结构鉴定 |
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| 引用本文： | 孔令义,裴月湖,李铣,朱廷儒,奥山徹.前胡香豆素A的分离和结构鉴定[J].药学学报,1993,28(6):432-436. |
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| 作者姓名： | 孔令义 裴月湖 李铣 朱廷儒 奥山徹 |
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| 作者单位： | 沈阳药学院天然药物研究室，沈阳药学院天然药物研究室，沈阳药学院天然药物研究室，沈阳药学院天然药物研究室，日本明治药科大学生药教室 沈阳 110015 中国药科大学植化教研室 南京 210009，沈阳 110015，沈阳 110015，沈阳 110015，东京 154 |
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| 摘 要： | 从中药白花前胡(Peucedanum praeruptorum Dunn)根中分离得到7个化合物,经理化常数和波谱数据的测定以及化学反应,鉴定为补骨脂素(Ⅱ)、5-甲氧基补骨脂素(Ⅲ)、8-甲氧基补骨脂素(Ⅳ)、北美芹素(Ⅴ)、peucedanocoumarin Ⅱ(Ⅵ)、β-谷甾醇(Ⅶ)和前胡香豆素A(Ⅷ)。Ⅷ为一新化合物,通过和凯林内酯的化学沟通确定了其绝对构型,化学结构为3′(R)-羟基-4′(E)-惕各酰氧基-3′,4′-二氢邪蒿内酯。Ⅱ～Ⅳ和Ⅶ为首次从白花前胡中分离得到。
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| 关 键 词： | 白花前胡 前胡香豆素A |
| 收稿时间： | 1992-07-27 |
ISOLATION AND STRUCTURE ELUCIDATION OF QIANHUCOUMARIN A |
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| LY Kong,YH Pei,X Li,TR Zhu and T Okuyama.ISOLATION AND STRUCTURE ELUCIDATION OF QIANHUCOUMARIN A[J].Acta Pharmaceutica Sinica,1993,28(6):432-436. |
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| Authors: | LY Kong YH Pei X Li TR Zhu and T Okuyama |
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| Abstract: | Seven compounds were isolated from the traditional Chinese Medicine Qianhu, roots of Peucedanum praeruptorum Dunn. Their structures were identified as psoralen (Ⅱ), 5-methoxyp soralen (Ⅲ), 8-methoxypsoralen (Ⅳ), pteryxin (Ⅴ), peucedanocoumarin Ⅱ (Ⅵ), β-sitosterol (Ⅶ) and qianhucoumarin A (Ⅷ) by physico-chemical constants and spectral analyses (UV, IR, 1HNMR, 13CNMR, ELMS). Ⅷ is a new compound with the structure of 3' (R)-hydroxy-4'(R)-tigloyloxy-3',4'-dihydroseslin. Its absolute configurations were determined by chemical correlation with known compounds. Ⅱ, Ⅲ, Ⅳ and Ⅶ were first isolated from this plant. |
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| Keywords: | Peucedanmn praeruptorum Qianhucoumarin A |
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