Lung cancer mortality and occupational exposure to asbestos among telephone linemen: a historical cohort study in France |
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Authors: | Meguellati-Hakkas Djamila Cyr Diane Stücker Isabelle Févotte Joëlle Pilorget Corinne Luce Danièle Guénel Pascal |
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Institution: | INSERM U754, IFR69, 16 avenue Paul Vaillant-Couturier, 94807 Villejuif Cedex, France. |
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Abstract: | OBJECTIVE: The authors studied the mortality by lung cancer in telephone linemen exposed to asbestos at low levels during installation of telephone cables. METHODS: Three hundred eight lung cancers deaths were identified in the cohort. Exposure to asbestos and to other occupational carcinogens was assessed using a job-exposure matrix. RESULTS: The relative risk for lung cancer death associated with an estimated exposure of approximately 2 f/cc-years was 2.1 (95% confidence interval = 1.1-4.0) as compared with workers exposed to less than 0.5 f/cc-years. Mean annual exposure or exposure duration were not clearly related to lung cancer. Adjustment for other occupational lung carcinogens did not change this finding. CONCLUSION: The observed mortality by lung cancer associated with asbestos exposure at low levels is higher than the prediction based on linear downward extrapolations from highly exposed occupational cohorts. |
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