Paclitaxel (Taxol)-Induced Killing of Leishmania major in Murine Macrophages |
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| Authors: | T. Mark Doherty Alan Sher Stefanie N. Vogel |
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| Affiliation: | Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892,1. and Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 208142. |
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| Abstract: | The antitumor drug paclitaxel (Taxol) has been demonstrated to be a lipopolysaccharide mimetic in murine macrophages. In this study, the capacity of paclitaxel to activate macrophages to become microbicidal for Leishmania major was examined. Paclitaxel and gamma interferon synergized to kill intracellular L. major in Lpsn, but not Lpsd, macrophages by a nitric oxide (NO·)-dependent mechanism. |
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