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The gene for apolipoprotein C-ll is closely linked to the gene for apolipoprotein E on chromosome 19 |
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| Authors: | S E Humphries K Berg L Gill A M Cumming F W Robertson A F H Stalenhoef R Williamson A-L Børresen |
| Institution: | Department of Biochemistry, St. Mary's Hospital Medical School, Norfolk Place, London, England;Institute of Medical Genetics, Blindern, Oslo, Norway;Department of Genetics, University of Aberdeen, Aberdeen, Scotland;Department of Medicine, Division of General Internal Medicine, University of Nijmegen, The Netherlands |
| Abstract: | We have used a common TaqI restriction fragment length polymorphism (RFLP) near the human apolipoprotein C-II (apoC-II) gene to study linkage with apolipoprotein E (apoE). The inheritance of the apoC-II RFLP was followed in seven families that were segregating for apoE protein variants. No recombinants were observed in 20 informative meioses, giving an overall lod score of > 4.0 at recombination fraction 0. We have also observed apparent linkage disequilibrium between apoE and the apoC-II RFLP. Taken together these results demonstrate that these two apolipoprotein genes are closely linked and confirm that the gene for apoC-II is on human chromosome 19. |
| Keywords: | ApoC-II apoE apoproteins chromosome 19 linkage lipoproteins RFLP |