Indications of partial hepatectomy for transplantable hepatocellular carcinoma with compensated cirrhosis |
| |
Authors: | Itamoto Toshiyuki Nakahara Hideki Tashiro Hirotaka Ohdan Hideki Hino Hiroshi Ochi Makoto Asahara Toshimasa |
| |
Affiliation: | Department of Surgery, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Science, Hiroshima University, 1-2-3, Kasumi, Minami-Ku, Hiroshima, 734-8551, Japan. titamoto@hiroshima-u.ac.jp |
| |
Abstract: | BACKGROUND: The appropriate treatment strategy for transplantable hepatocellular carcinoma (HCC) patients with compensated cirrhosis remains controversial. METHODS: Surgical outcomes were reviewed in 136 cirrhotic patients with transplantable HCC who had undergone partial hepatectomy. Transplantable HCC was defined as that corresponding to Milan's criteria. RESULTS: The adverse prognostic factors for both survival and disease-free survival were histologic surgical margin of 5 mm or less, Child-Pugh B, and the presence of hepatitis C virus infection. The overall 5-year survival and disease-free survival rates of patients with 1 or none of the adverse prognostic factors were 73% and 33%, respectively, whereas those of patients with 2 or 3 adverse prognostic factors were 36% and 17%, respectively. CONCLUSIONS: Transplantable HCC patients with 2 or 3 adverse prognostic factors should be considered candidates for liver transplantation, whereas patients with only 1 or none of the adverse prognostic factors are good candidates for partial hepatectomy. |
| |
Keywords: | Hepatocellular carcinoma Hepatectomy Cirrhosis Liver transplantation Milan’s criteria |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|