甲减患者总同型半胱氨酸水平及其相关因素分析

目的：探讨甲减患血浆总同型半胱氨酸（tHcy)的变化及其与叶酸，维生素B12，血清胆固醇的相关关系，方法：应用荧光偏振免疫发光技术测定45例甲减患及48例正常对照tHcy，叶酸，维生素B12水平，应用生化技术测定血清总胆固醇；同一参数在甲减组与对照组间进行t 检验,tHcy 与各参数间的关系采用Spearman等级相关，结果：甲减组tHcy及血清胆固醇显高于对照组；甲减组叶酸及维生素B12显代于对照组，甲减患tHcy与叶酸，维生素B12分别呈显负相关，与胆固醇呈正相关，但无统计学意义。结论：甲减患tHcy和胆固醇升高可加速其动脉硬化的发生及发展，加速冠心病的进程，补充叶酸及维生素B12治疗有望在一定程度上降低tHcy的水平，从而降低甲减患冠心病的发生率。

The Change of Total Homocysteine Levels in Hypothyroidism

Objective To investigate the changes of serum tHcy, and the relationship between tHcy and folacin, cobalamin as well as cholesterol.Methods 45 patients with hypothyroidism and 48 control subjects were recruited to the study. The tHcy, folacin,cobalamin were measured using FPLIA technology. Serum cholesterol was detected with biochemical methods.The relationship between tHcy and the other parameters were presented as Spearman rank correlations.Results Plasma tHcy and serum cholesterol were higher in patients with hypothyroidism than in control subjects. Serum folacin and cobalamin were lower in patients group than in control group.The tHcy was negatively correlated with cobalamin and folacin.Conclusions The increase of tHcy and cholesterol observed in hypothyroidism patients may contribute to high cardiovascular risk.Supplementing cobalamin and folacin may decrease plasma tHcy level in hypothyroidism.