不同剂量丙种球蛋白联合激素治疗小儿特发性血小板减少性紫癜疗效对比分析

目的：研究探讨不同剂量丙种球蛋白联合激素治疗小儿特发性血小板减少性紫癜的临床疗效。方法整群选取2014年2月—2016年1月于该院诊治的75例小儿特发性血小板减少性紫癜患者，随机分为对照组、大剂量组及小剂量组三组，每组均为25例患儿；观察与比较3组患儿治疗后的血小板上升时间、出血停止时间及血小板恢复至正常水平的时间等临床疗效指标和临床治疗有效率等。结果与对照组相比，大、小剂量组患儿治疗后的血小板上升时间(3.08±1.27)、(3.15±1.31)d，出血停止时间(3.36±1.41)、(3.28±1.25)d及血小板恢复至正常水平的时间(5.27±1.13)、(5.34±1.22)d等临床疗效指标均明显优于对照组，其临床治疗有效率92.00%亦均高于对照组80.0%，其差异具有统计学意义（P﹤0.05)。结论联合运用丙种球蛋白和激素治疗更能有效快速的上升血小板及加快止血，提高临床治疗有效率，同时不同剂量的丙种球蛋白治疗效果相当，小剂量的丙种球蛋白治疗更能有效降低经济负担，值得临床上进一步应用推广。

Clinical Effect of Different Doses of Gamma Globulin and Hormone Therapy for Idiopathic Thrombocytopenic Purpura in Children

Objective To compare the curative effect of different doses of gamma globulin and hormone therapy for Idio-pathic thrombocytopenic purpura in children. Methods Selected February 2014 to January 2016 in my hospital for treat-ment of 75 cases of children with idiopathic thrombocytopenic purpura patients decreased and randomly assigned for control group, high dose group and low dose group of three groups, each group had 25 cases; observation and compared among the three groups after treatment in children with platelet rise time, bleeding stop time and platelet recovery to normal levels and other clinical indicators and clinical treatment effective rate etc. Results Compared with the control group, after treatment with large and small dose groups of children with platelet rise time (3.08±1.27),(3.15±1.31), bleeding time to stop (3.36± 1.41, 3.28±1.25) and platelet recovery to normal level (527±1.13),(534±1.22) clinical efficacy indexes were significantly bet-ter than the control group. The clinical treatment has efficiency 92% were higher than those in the control group 80.0%, the difference has statistical significance (P﹤ 0.05). Conclusion The gamma globulin and hormone therapy can efficiently in-crease the blood platelet, shorten the time of stopping bleeding and improve the effective rate. Since the different doses of gamma globulin have a fair effect, the low dose of gamma globulin can reduce the patient’s economic burden. It is worthy of clinical application and promotion.