不同类型降压药物对老年原发性高血压患者动脉僵硬度的影响分析

目的：研究两种不同降压药物在治疗老年原发性高血压后患者的动脉僵硬度的变化。方法在该院于2014年5月—2015年9月收治的老年原发性高血压患者中随机选出120例作为观察对象,按照口服的降压药物类型分成两组,A组57例患者服用缬沙坦,B组63例患者服用马来酸左旋氨氯地平；统计分析两组患者治疗前后的舒张压、收缩压、超敏C反应蛋白、肱踝脉搏波传导速度等指标。结果A组患者治疗后的收缩压、舒张压分别为(113.8±7.6)mmHg、(72.4±7.3)mmHg；B组为(111.2±8.2)mmHg、(70.2±8.4)mmHg,组间差异无统计学意义,P﹥0.05；A组患者的hs-CRP、baPWV分别为(8.4±0.7)mg/L、(9.5±1.1)m/s；B组为(7.0±0.5)mg/L、(7.2±1.0)m/s；B组明显低于A组,P﹤0.05。结论在老年原发性高血压的治疗中采用马来酸左旋氨氯地平治疗能在取得满意降压效果的情况下改善动脉僵硬度,对于降低心血管事件风险具有重要意义。

Different Types of Antihypertensive Drugs for the Elderly Patients with Es-sential Hypertension (eh) Impact Analysis of Arterial Stiffness

Objective To study the two different kinds of antihypertensive drugs in the treatment of senile primary hyper-tension patients after the change of arterial stiffness. Methods In our hospital in May 2014 — September 2015 elderly pa-tients with essential hypertension admitted 120 cases were randomly selected as the observed object, according to the type of oral antihypertensive drugs is divided into two groups, group A 57 patients taking hydrochlorothiazide, group B 63 cases treated with valsartan; Statistical analysis of two groups of patients before and after treatment of diastolic and systolic blood pressure, arterial elasticity index, brachial ankle pulse wave conduction velocity, etc. Results Patients in group A were treated with systolic blood pressure, diastolic blood pressure (113.8±7.6)mmHg and (72.4±7.3)mmHg;group B for (111.2± 8.2)mmHg and (70.2±8.4)mmHg, group and there was no significant difference (P> 0.05); a group of patients with HS CRP, baPWV respectively (8.4 ±0.7)mg/L, (9.5 ±1.1)m/s; group B for (7.0 ±0.5)mg/L, (7.2 ±1.0)m/s; B group was signifi-cantly lower than that in group A, (P < 0.05), respectively.Conclusion In the treatment of senile primary hypertension treated with valsartan can under the condition of the antihypertensive effect is satisfactory, improve arterial stiffness is of great significance to reduce the risk of cardiovascular events.