p16和Ki-67蛋白，TLR3在宫颈病变分流诊断中的应用

目的：评估p16和Ki-67蛋白,TLR3检查在宫颈病变分流诊断中的临床价值。方法整群选取该院2014年10月一2016年8月妇产科门诊阴道镜下活检病理诊断各类宫颈病变153例分别进行p16和Ki-67,TLR3检测。采用免疫组化技术(S-P法)检测p16及Ki-67,TLR3的表达。结果在慢性宫颈炎、CINI级、CINⅡ级、CINⅢ级中,p16阳性率为13.21％、58.24%,96.25％、97.51％,Ki-67阳性率为10.05％、61.22％、94.12％、96.05％,TLR3阳性率为11.04％、62.32％、95.02％、97.05％,p16与Ki67,TLR3阳性率呈递增趋势,差异有统计学意义。结论 P16和Ki-67, TLR3对宫颈病变分流诊断有重要辅助诊断价值,精确指导宫颈病变的诊断与治疗,预防宫颈癌的发生。

Application of p16,Ki-67 Protein and TLR3 in Shunt Diagnosis of Cervical Lesions

Objective To evaluate the application of p16, Ki-67 protein and TLR3 in shunt diagnosis of cervical lesions. Methods Group selection from October 2014 to August 2016 153 specimens onfirmed by pathological diagnosis of cervical lesions and can not determine the level of cervical lesions after Biopsying under colposcope. p16,Ki-67,TLR3 were detected with Envision methode. Results In chronic cervicitis, CINⅠ, CINⅡ, CINⅢ, the positive expression rate of p16 for 58.24%and 13.21% and 96.25% and 97.51%, the positive rate of Ki-67 was 10.05% and 61.22% and 94.12% and 96.05%, TLR3 positive rate was 11.04%, 62.32%, 95.02%, 97.05%, p16 and Ki-67,TLR3 positive rate was increased, the difference is significant. Conclusion P16 and Ki-67, TLR3 is important auxiliary diagnostic value for shunt in the diagnosis of cervical lesions, accurate guide the diagnosis and treatment of cervical lesions, prevent the happening of the cervical cancer.